PARP1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use PARP1-specific vectors and viral particles designed for reliable PARP1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including PARP1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human PARP1 Gene Overview
| Gene Name | poly(ADP-ribose) polymerase 1 |
|---|---|
| Gene Symbol | PARP1 |
| Synonyms | PARP,PARS,PPOL,ADPRT,ARTD1,ADPRT1,PARP-1,ADPRT 1,pADPRT-1,Poly-PARP |
| NCBI ID | 142 |
| Ensembl ID | ENSG00000143799 |
| Uniprot ID | P09874 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Human PARP1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC136022 | View Product |
| AAV Vector & Virus | Long-term expression | VC136022 | View Product |
| Adenovirus | Transient expression | A136022 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG136022 | View Product |
| Gene knockout (non-viral) | PG136022 | View Product | |
| Gene knockout (AAV) | VG136022 | View Product | |
| CRISPR Activation | Gene activation | LA136022 | View Product |
| siRNA Tools | Gene knockdown (AAV) | VS136022 | View Product |
| ORF Vector | Template DNA | PC136022 | View Product |
Mouse Parp1 Gene Overview
| Gene Name | poly (ADP-ribose) polymerase family, member 1 |
|---|---|
| Gene Symbol | Parp1 |
| Synonyms | PARP,PPOL,ARTD1,Adprp,Adprt1,msPARP,parp-1,sPARP-1,5830444G22Rik |
| NCBI ID | 11545 |
| Ensembl ID | ENSMUSG00000026496 |
| Uniprot ID | P11103 |
| Gene Type | Protein coding |
Gene Summary
Enables chromatin binding activity and pentosyltransferase activity. Involved in several processes, including decidualization; negative regulation of adipose tissue development; and negative regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including DNA metabolic process; behavioral response to cocaine; and regulation of macromolecule metabolic process. Located in cytoplasm; nucleolus; and nucleoplasm. Part of protein-containing complex. Is active in chromatin; nucleus; and site of DNA damage. Is expressed in several structures, including brain; gonad; hemolymphoid system; intestine; and retina. Human ortholog(s) of this gene implicated in several diseases, including arthritis; bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Parp1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC436022 | View Product |
| AAV Vector & Virus | Long-term expression | VC436022 | View Product |
| Adenovirus | Transient expression | A436022 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG436022 | View Product |
| Gene knockout (non-viral) | PG436022 | View Product | |
| Gene knockout (AAV) | VG436022 | View Product | |
| CRISPR Activation | Gene activation | LA436022 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS436022 | View Product |
| Gene knockdown (AAV) | VS436022 | View Product | |
| ORF Vector | Template DNA | PC436022 | View Product |
Rat Parp1 Gene Overview
| Gene Name | poly (ADP-ribose) polymerase 1 |
|---|---|
| Gene Symbol | Parp1 |
| Synonyms | ARTD1,Adprt,Parp-1 |
| NCBI ID | 25591 |
| Ensembl ID | ENSRNOG00000003084 |
| Uniprot ID | P27008 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including NAD+ poly-ADP-ribosyltransferase activity; R-SMAD binding activity; and enzyme binding activity. Involved in several processes, including cellular response to amyloid-beta; regulation of gene expression; and regulation of intracellular signal transduction. Located in nucleus. Used to study congestive heart failure; middle cerebral artery infarction; and transient cerebral ischemia. Biomarker of several diseases, including borna disease; cerebrovascular disease (multiple); kidney failure; perinatal necrotizing enterocolitis; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including arthritis; bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Parp1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC636022 | View Product |
| AAV Vector & Virus | Long-term expression | VC636022 | View Product |
| Adenovirus | Transient expression | A636022 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG636022 | View Product |
| Gene knockout (non-viral) | PG636022 | View Product | |
| Gene knockout (AAV) | VG636022 | View Product | |
| CRISPR Activation | Gene activation | LA636022 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS636022 | View Product |
| Gene knockdown (AAV) | VS636022 | View Product | |
| ORF Vector | Template DNA | PC636022 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |