PAX6 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use PAX6-specific vectors and viral particles designed for reliable PAX6 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including PAX6 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human PAX6 Gene Overview
| Gene Name | paired box 6 |
|---|---|
| Gene Symbol | PAX6 |
| Synonyms | AN,AN1,AN2,FVH1,MGDA,WAGR,ASGD5,D11S812E |
| NCBI ID | 5080 |
| Ensembl ID | ENSG00000007372 |
| Uniprot ID | P26367 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain. [provided by RefSeq, Mar 2019]
Human PAX6 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC136062 | View Product |
| AAV Vector & Virus | Long-term expression | VC136062 | View Product |
| Adenovirus | Transient expression | A136062 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG136062 | View Product |
| Gene knockout (non-viral) | PG136062 | View Product | |
| Gene knockout (AAV) | VG136062 | View Product | |
| CRISPR Activation | Gene activation | LA136062 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS136062 | View Product |
| Gene knockdown (AAV) | VS136062 | View Product | |
| ORF Vector | Template DNA | PC136062 | View Product |
Mouse Pax6 Gene Overview
| Gene Name | paired box 6 |
|---|---|
| Gene Symbol | Pax6 |
| Synonyms | Dey,Sey,AEY11,Pax-6,Gsfaey11,1500038E17Rik |
| NCBI ID | 18508 |
| Ensembl ID | ENSMUSG00000027168 |
| Uniprot ID | P63015 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a homeobox-containing protein that functions as a regulator of transcription. It plays a key role in the development of neural tissues, particularly the eye. Activity of this protein is also required for expression of glucagon in the pancreas. This gene is regulated by multiple enhancers located up to tens or hundreds of kilobases upstream and downstream of the transcription start sites. Mutations in this gene or deletion of these regulatory elements results in severe defects in eye development. Alternative splicing and the use of alternative promoters results in multiple transcript variants, some of which encode proteins that lack the N-terminal paired domain. [provided by RefSeq, Jul 2015]
Mouse Pax6 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC436062 | View Product |
| Stable overexpression | LC536062 | View Product | |
| AAV Vector & Virus | Long-term expression | VC436062 | View Product |
| Long-term expression | VC536062 | View Product | |
| Adenovirus | Transient expression | A436062 | View Product |
| Transient expression | A536062 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG436062 | View Product |
| Gene knockout (non-viral) | PG436062 | View Product | |
| Gene knockout (AAV) | VG436062 | View Product | |
| CRISPR Activation | Gene activation | LA436062 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS436062 | View Product |
| Gene knockdown (AAV) | VS436062 | View Product | |
| ORF Vector | Template DNA | PC436062 | View Product |
| Template DNA | PC536062 | View Product |
Rat Pax6 Gene Overview
| Gene Name | paired box 6 |
|---|---|
| Gene Symbol | Pax6 |
| Synonyms | |
| NCBI ID | 25509 |
| Ensembl ID | ENSRNOG00000004410 |
| Uniprot ID | P63016 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including endocrine pancreas development; nervous system development; and positive regulation of macromolecule biosynthetic process. Located in chromatin. Used to study autistic disorder. Biomarker of Smith-Lemli-Opitz syndrome and transient cerebral ischemia. Human ortholog(s) of this gene implicated in bilateral optic nerve hypoplasia; eye disease (multiple); glucose intolerance; and paranoid schizophrenia. Orthologous to human PAX6 (paired box 6). [provided by Alliance of Genome Resources, Jul 2025]
Rat Pax6 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC636062 | View Product |
| AAV Vector & Virus | Long-term expression | VC636062 | View Product |
| Adenovirus | Transient expression | A636062 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG636062 | View Product |
| Gene knockout (non-viral) | PG636062 | View Product | |
| Gene knockout (AAV) | VG636062 | View Product | |
| CRISPR Activation | Gene activation | LA636062 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS636062 | View Product |
| Gene knockdown (AAV) | VS636062 | View Product | |
| ORF Vector | Template DNA | PC636062 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |