PCSK9 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use PCSK9-specific vectors and viral particles designed for reliable PCSK9 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including PCSK9 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human PCSK9 Gene Overview
| Gene Name | proprotein convertase subtilisin/kexin type 9 |
|---|---|
| Gene Symbol | PCSK9 |
| Synonyms | FH3,PC9,FHCL3,NARC1,LDLCQ1,NARC-1,HCHOLA3 |
| NCBI ID | 255738 |
| Ensembl ID | ENSG00000169174 |
| Uniprot ID | Q8NBP7 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Human PCSK9 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC136238 | View Product |
| AAV Vector & Virus | Long-term expression | VC136238 | View Product |
| Adenovirus | Transient expression | A136238 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG136238 | View Product |
| Gene knockout (non-viral) | PG136238 | View Product | |
| Gene knockout (AAV) | VG136238 | View Product | |
| CRISPR Activation | Gene activation | LA136238 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS136238 | View Product |
| Gene knockdown (AAV) | VS136238 | View Product | |
| ORF Vector | Template DNA | PC136238 | View Product |
Mouse Pcsk9 Gene Overview
| Gene Name | proprotein convertase subtilisin/kexin type 9 |
|---|---|
| Gene Symbol | Pcsk9 |
| Synonyms | FH3,PC9,Narc1,HCHOLA3 |
| NCBI ID | 100102 |
| Ensembl ID | ENSMUSG00000044254 |
| Uniprot ID | Q80W65 |
| Gene Type | Protein coding |
Gene Summary
Enables apolipoprotein binding activity; lipoprotein particle binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including cellular response to insulin stimulus; liver development; and regulation of neuron apoptotic process. Acts upstream of or within several processes, including low-density lipoprotein receptor particle metabolic process; regulation of low-density lipoprotein particle receptor catabolic process; and triglyceride metabolic process. Located in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and extracellular space. Is expressed in alimentary system; brain; genitourinary system; liver; and skin. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Pcsk9 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC436238 | View Product |
| AAV Vector & Virus | Long-term expression | VC436238 | View Product |
| Adenovirus | Transient expression | A436238 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG436238 | View Product |
| Gene knockout (non-viral) | PG436238 | View Product | |
| Gene knockout (AAV) | VG436238 | View Product | |
| CRISPR Activation | Gene activation | LA436238 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS436238 | View Product |
| Gene knockdown (AAV) | VS436238 | View Product | |
| ORF Vector | Template DNA | PC436238 | View Product |
Rat Pcsk9 Gene Overview
| Gene Name | proprotein convertase subtilisin/kexin type 9 |
|---|---|
| Gene Symbol | Pcsk9 |
| Synonyms | PC9,Narc1,NARC-1 |
| NCBI ID | 298296 |
| Ensembl ID | ENSRNOG00000006280 |
| Uniprot ID | P59996 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including lipoprotein particle binding activity; lipoprotein particle receptor binding activity; and serine-type endopeptidase activity. Involved in several processes, including cellular response to insulin stimulus; cholesterol homeostasis; and protein autoprocessing. Located in extracellular space. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9). [provided by Alliance of Genome Resources, Jul 2025]
Rat Pcsk9 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC636238 | View Product |
| AAV Vector & Virus | Long-term expression | VC636238 | View Product |
| Adenovirus | Transient expression | A636238 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG636238 | View Product |
| Gene knockout (non-viral) | PG636238 | View Product | |
| Gene knockout (AAV) | VG636238 | View Product | |
| CRISPR Activation | Gene activation | LA636238 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS636238 | View Product |
| Gene knockdown (AAV) | VS636238 | View Product | |
| ORF Vector | Template DNA | PC636238 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |