PDCD1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use PDCD1-specific vectors and viral particles designed for reliable PDCD1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including PDCD1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human PDCD1 Gene Overview
| Gene Name | programmed cell death 1 |
|---|---|
| Gene Symbol | PDCD1 |
| Synonyms | PD1,PD-1,CD279,SLEB2,hPD-1,hPD-l,hSLE1,ADMIO4,AIMTBS |
| NCBI ID | 5133 |
| Ensembl ID | ENSG00000188389 |
| Uniprot ID | Q15116 |
| Gene Type | Protein coding |
Gene Summary
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]
Human PDCD1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC136257 | View Product |
| AAV Vector & Virus | Long-term expression | VC136257 | View Product |
| Adenovirus | Transient expression | A136257 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG136257 | View Product |
| Gene knockout (non-viral) | PG136257 | View Product | |
| Gene knockout (AAV) | VG136257 | View Product | |
| CRISPR Activation | Gene activation | LA136257 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS136257 | View Product |
| Gene knockdown (AAV) | VS136257 | View Product | |
| ORF Vector | Template DNA | PC136257 | View Product |
Mouse Pdcd1 Gene Overview
| Gene Name | programmed cell death 1 |
|---|---|
| Gene Symbol | Pdcd1 |
| Synonyms | PD-1,Pdc1,Ly101 |
| NCBI ID | 18566 |
| Ensembl ID | ENSMUSG00000026285 |
| Uniprot ID | Q02242 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable signaling receptor activity. Involved in negative regulation of immune response. Acts upstream of or within negative regulation of B cell apoptotic process; negative regulation of tolerance induction; and positive regulation of T cell apoptotic process. Located in external side of plasma membrane. Is expressed in retina. Used to study dilated cardiomyopathy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Pdcd1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC436257 | View Product |
| AAV Vector & Virus | Long-term expression | VC436257 | View Product |
| Adenovirus | Transient expression | A436257 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG436257 | View Product |
| Gene knockout (non-viral) | PG436257 | View Product | |
| Gene knockout (AAV) | VG436257 | View Product | |
| CRISPR Activation | Gene activation | LA436257 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS436257 | View Product |
| Gene knockdown (AAV) | VS436257 | View Product | |
| ORF Vector | Template DNA | PC436257 | View Product |
Rat Pdcd1 Gene Overview
| Gene Name | programmed cell death 1 |
|---|---|
| Gene Symbol | Pdcd1 |
| Synonyms | |
| NCBI ID | 301626 |
| Ensembl ID | ENSRNOG00000019043 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable signaling receptor activity. Predicted to be involved in negative regulation of T cell activation; negative regulation of T cell mediated immune response to tumor cell; and positive regulation of T cell apoptotic process. Predicted to act upstream of or within negative regulation of B cell apoptotic process and negative regulation of tolerance induction. Predicted to be active in external side of plasma membrane. Biomarker of anti-basement membrane glomerulonephritis; periodontitis; and pre-eclampsia. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1). [provided by Alliance of Genome Resources, Apr 2025]
Rat Pdcd1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC636257 | View Product |
| AAV Vector & Virus | Long-term expression | VC636257 | View Product |
| Adenovirus | Transient expression | A636257 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG636257 | View Product |
| Gene knockout (non-viral) | PG636257 | View Product | |
| Gene knockout (AAV) | VG636257 | View Product | |
| CRISPR Activation | Gene activation | LA636257 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS636257 | View Product |
| Gene knockdown (AAV) | VS636257 | View Product | |
| ORF Vector | Template DNA | PC636257 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |