PIEZO1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use PIEZO1-specific vectors and viral particles designed for reliable PIEZO1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including PIEZO1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human PIEZO1 Gene Overview
| Gene Name | piezo type mechanosensitive ion channel component 1 (Er blood group) |
|---|---|
| Gene Symbol | PIEZO1 |
| Synonyms | ER,DHS,Mib,LMPH3,FAM38A,LMPHM6 |
| NCBI ID | 9780 |
| Ensembl ID | ENSG00000103335 |
| Uniprot ID | Q92508 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. [provided by RefSeq, Jul 2015]
Human PIEZO1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG120014 | View Product |
| Gene knockout (non-viral) | PG120014 | View Product | |
| Gene knockout (AAV) | VG120014 | View Product | |
| CRISPR Activation | Gene activation | LA120014 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS120014 | View Product |
| Gene knockdown (AAV) | VS120014 | View Product | |
| ORF Vector | Template DNA | PC136641 | View Product |
Mouse Piezo1 Gene Overview
| Gene Name | piezo-type mechanosensitive ion channel component 1 |
|---|---|
| Gene Symbol | Piezo1 |
| Synonyms | Fam38a,mKIAA0233,9630020g22 |
| NCBI ID | 234839 |
| Ensembl ID | ENSMUSG00000014444 |
| Uniprot ID | E2JF22 |
| Gene Type | Protein coding |
Gene Summary
Enables identical protein binding activity and mechanosensitive monoatomic cation channel activity. Involved in monoatomic cation transport and positive regulation of myotube differentiation. Acts upstream of or within detection of mechanical stimulus and regulation of membrane potential. Located in cuticular plate; plasma membrane; and stereocilium. Is expressed in several structures, including brain; cardiovascular system; hemolymphoid system; liver; and lung. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1 and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1 (Er blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Piezo1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Rat Piezo1 Gene Overview
| Gene Name | piezo-type mechanosensitive ion channel component 1 |
|---|---|
| Gene Symbol | Piezo1 |
| Synonyms | Mib,Fam38a |
| NCBI ID | 361430 |
| Ensembl ID | ENSRNOG00000056786 |
| Uniprot ID | Q0KL00 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable identical protein binding activity and mechanosensitive monoatomic cation channel activity. Predicted to be involved in several processes, including cellular response to mechanical stimulus; positive regulation of cell-cell adhesion mediated by integrin; and positive regulation of myotube differentiation. Predicted to be located in cuticular plate and stereocilium. Predicted to be active in endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1 and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1 (Er blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Rat Piezo1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |