PKM Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use PKM-specific vectors and viral particles designed for reliable PKM overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including PKM CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human PKM Gene Overview
| Gene Name | pyruvate kinase M1/2 |
|---|---|
| Gene Symbol | PKM |
| Synonyms | PK3,TCB,p58,OIP3,PKM2,CTHBP,THBP1,HEL-S-30 |
| NCBI ID | 5315 |
| Ensembl ID | ENSG00000067225 |
| Uniprot ID | P14618 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]
Human PKM Related Products
| Product Type | Key Applications | Cat. No. | Product |
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Mouse Pkm Gene Overview
| Gene Name | pyruvate kinase, muscle |
|---|---|
| Gene Symbol | Pkm |
| Synonyms | Pk3,Pk-2,Pk-3,Pkm2 |
| NCBI ID | 18746 |
| Ensembl ID | ENSMUSG00000032294 |
| Uniprot ID | P52480 |
| Gene Type | Protein coding |
Gene Summary
Enables mRNA binding activity and pyruvate kinase activity. Involved in canonical glycolysis and positive regulation of cytoplasmic translation. Located in cilium and rough endoplasmic reticulum. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Pkm Related Products
| Product Type | Key Applications | Cat. No. | Product |
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Rat Pkm Gene Overview
| Gene Name | pyruvate kinase M1/2 |
|---|---|
| Gene Symbol | Pkm |
| Synonyms | PK,Pk3,Pkm2,PKM12 |
| NCBI ID | 25630 |
| Ensembl ID | ENSRNOG00000011329 |
| Uniprot ID | P11980 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including ADP binding activity; pyruvate kinase activity; and thyroid hormone binding activity. Involved in several processes, including monocarboxylic acid metabolic process; protein homotetramerization; and response to insulin. Part of pyruvate kinase complex. Biomarker of hypertension. Orthologous to human PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Pkm Related Products
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Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |