PPARGC1A Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use PPARGC1A-specific vectors and viral particles designed for reliable PPARGC1A overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including PPARGC1A CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human PPARGC1A Gene Overview
| Gene Name | PPARG coactivator 1 alpha |
|---|---|
| Gene Symbol | PPARGC1A |
| Synonyms | LEM6,PGC1,PGC1A,PGC-1v,PPARGC1,PGC-1alpha,PGC-1(alpha) |
| NCBI ID | 10891 |
| Ensembl ID | ENSG00000109819 |
| Uniprot ID | Q9UBK2 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]
Human PPARGC1A Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC137299 | View Product |
| AAV Vector & Virus | Long-term expression | VC137299 | View Product |
| Adenovirus | Transient expression | A137299 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG137299 | View Product |
| Gene knockout (non-viral) | PG137299 | View Product | |
| Gene knockout (AAV) | VG137299 | View Product | |
| CRISPR Activation | Gene activation | LA137299 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS137299 | View Product |
| Gene knockdown (AAV) | VS137299 | View Product | |
| ORF Vector | Template DNA | PC137299 | View Product |
Mouse Ppargc1a Gene Overview
| Gene Name | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha |
|---|---|
| Gene Symbol | Ppargc1a |
| Synonyms | Pgc1,PGC-1,Pgco1,Gm11133,Ppargc1,Pgc-1alpha,A830037N07Rik,PPARGC-1-alpha |
| NCBI ID | 19017 |
| Ensembl ID | ENSMUSG00000029167 |
| Uniprot ID | O70343 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Mouse Ppargc1a Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC437299 | View Product |
| AAV Vector & Virus | Long-term expression | VC437299 | View Product |
| Adenovirus | Transient expression | A437299 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG437299 | View Product |
| Gene knockout (non-viral) | PG437299 | View Product | |
| Gene knockout (AAV) | VG437299 | View Product | |
| CRISPR Activation | Gene activation | LA437299 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS437299 | View Product |
| Gene knockdown (AAV) | VS437299 | View Product | |
| ORF Vector | Template DNA | PC437299 | View Product |
Rat Ppargc1a Gene Overview
| Gene Name | PPARG coactivator 1 alpha |
|---|---|
| Gene Symbol | Ppargc1a |
| Synonyms | PGCvf,LRPGC1,PGC-1v,PGCvf1,PGCvf-1,Ppargc1 |
| NCBI ID | 83516 |
| Ensembl ID | ENSRNOG00000004473 |
| Uniprot ID | Q9QYK2 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including alpha-tubulin binding activity; nuclear estrogen receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including cellular response to hexose stimulus; regulation of primary metabolic process; and regulation of smooth muscle cell proliferation. Located in several cellular components, including apical dendrite; cytosolic ribosome; and euchromatin. Used to study several diseases, including glucose metabolism disease (multiple); heart disease (multiple); neurodegenerative disease (multiple); sciatic neuropathy; and steatotic liver disease (multiple). Biomarker of several diseases, including Huntington's disease; glucose metabolism disease (multiple); liver disease (multiple); placental insufficiency; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; metabolic dysfunction-associated steatotic liver disease; neurodegenerative disease (multiple); and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ppargc1a Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC637299 | View Product |
| AAV Vector & Virus | Long-term expression | VC637299 | View Product |
| Adenovirus | Transient expression | A637299 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG637299 | View Product |
| Gene knockout (non-viral) | PG637299 | View Product | |
| Gene knockout (AAV) | VG637299 | View Product | |
| CRISPR Activation | Gene activation | LA637299 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS637299 | View Product |
| Gene knockdown (AAV) | VS637299 | View Product | |
| ORF Vector | Template DNA | PC637299 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |