PRKN Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use PRKN-specific vectors and viral particles designed for reliable PRKN overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including PRKN CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human PRKN Gene Overview
| Gene Name | parkin RBR E3 ubiquitin protein ligase |
|---|---|
| Gene Symbol | PRKN |
| Synonyms | PDJ,AR-JP,LPRS2,PARK2 |
| NCBI ID | 5071 |
| Ensembl ID | ENSG00000185345 |
| Uniprot ID | O60260 |
| Gene Type | Protein coding |
Gene Summary
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]
Human PRKN Related Products
| Product Type | Key Applications | Cat. No. | Product |
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Mouse Prkn Gene Overview
| Gene Name | parkin RBR E3 ubiquitin protein ligase |
|---|---|
| Gene Symbol | Prkn |
| Synonyms | Park2 |
| NCBI ID | 50873 |
| Ensembl ID | ENSMUSG00000023826 |
| Uniprot ID | Q9WVS6 |
| Gene Type | Protein coding |
Gene Summary
Enables ubiquitin protein ligase activity. Involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway; positive regulation of dendrite extension; and positive regulation of protein metabolic process. Acts upstream of or within several processes, including catecholamine metabolic process; chemical synaptic transmission; and startle response. Located in mitochondrion; neuron projection; and nucleus. Part of protein-containing complex. Is active in dopaminergic synapse. Is expressed in several structures, including face; nervous system; pancreas; sensory organ; and skeleton. Used to study Parkinson's disease 2. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; lung cancer; and ovarian cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Prkn Related Products
| Product Type | Key Applications | Cat. No. | Product |
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Rat Prkn Gene Overview
| Gene Name | parkin RBR E3 ubiquitin protein ligase |
|---|---|
| Gene Symbol | Prkn |
| Synonyms | Park,Park2 |
| NCBI ID | 56816 |
| Ensembl ID | ENSRNOG00000055547 |
| Uniprot ID | Q9JK66 |
| Gene Type | Protein coding |
Gene Summary
Enables protein kinase binding activity. Involved in several processes, including cellular response to amino acid stimulus; modulation of chemical synaptic transmission; and regulation of apoptotic process. Located in several cellular components, including Golgi membrane; neuronal cell body; and synaptic vesicle. Is active in glutamatergic synapse; postsynapse; and synaptic vesicle membrane. Used to study Parkinson's disease. Biomarker of metabolic dysfunction-associated steatohepatitis and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; lung cancer; and ovarian cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Jul 2025]
Rat Prkn Related Products
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Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |