PTEN Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use PTEN-specific vectors and viral particles designed for reliable PTEN overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including PTEN CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human PTEN Gene Overview
| Gene Name | phosphatase and tensin homolog |
|---|---|
| Gene Symbol | PTEN |
| Synonyms | BZS,DEC,CWS1,GLM2,MHAM,TEP1,MMAC1,PTEN1,10q23del,PTENbeta,PTENgama |
| NCBI ID | 5728 |
| Ensembl ID | ENSG00000171862 |
| Uniprot ID | P60484 |
| Gene Type | Protein coding |
Gene Summary
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Human PTEN Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC138072 | View Product |
| AAV Vector & Virus | Long-term expression | VC138072 | View Product |
| Adenovirus | Transient expression | A238072 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG138072 | View Product |
| Gene knockout (non-viral) | PG138072 | View Product | |
| Gene knockout (AAV) | VG138072 | View Product | |
| CRISPR Activation | Gene activation | LA138072 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS138072 | View Product |
| Gene knockdown (AAV) | VS138072 | View Product | |
| ORF Vector | Template DNA | PC138072 | View Product |
Mouse Pten Gene Overview
| Gene Name | phosphatase and tensin homolog |
|---|---|
| Gene Symbol | Pten |
| Synonyms | TEP1,MMAC1,PTENbeta,2310035O07Rik,A130070J02Rik,B430203M17Rik |
| NCBI ID | 19211 |
| Ensembl ID | ENSMUSG00000013663 |
| Uniprot ID | O08586 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. [provided by RefSeq, Sep 2015]
Mouse Pten Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC438072 | View Product |
| AAV Vector & Virus | Long-term expression | VC438072 | View Product |
| Adenovirus | Transient expression | A438072 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG438072 | View Product |
| Gene knockout (non-viral) | PG438072 | View Product | |
| Gene knockout (AAV) | VG438072 | View Product | |
| CRISPR Activation | Gene activation | LA438072 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS438072 | View Product |
| Gene knockdown (AAV) | VS438072 | View Product | |
| ORF Vector | Template DNA | PC438072 | View Product |
Rat Pten Gene Overview
| Gene Name | phosphatase and tensin homolog |
|---|---|
| Gene Symbol | Pten |
| Synonyms | Mmac,TEP1,MMAC1 |
| NCBI ID | 50557 |
| Ensembl ID | ENSRNOG00000020723 |
| Uniprot ID | O54857 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including PDZ domain binding activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; dephosphorylation; and negative regulation of developmental growth. Located in dendritic spine and postsynaptic membrane. Is active in postsynaptic cytosol. Used to study portal hypertension and substance-related disorder. Biomarker of several diseases, including acute myocardial infarction; glucose metabolism disease (multiple); liver disease (multiple); retinal disease (multiple); and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Jul 2025]
Rat Pten Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC638072 | View Product |
| AAV Vector & Virus | Long-term expression | VC638072 | View Product |
| Adenovirus | Transient expression | A638072 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG638072 | View Product |
| Gene knockout (non-viral) | PG638072 | View Product | |
| Gene knockout (AAV) | VG638072 | View Product | |
| CRISPR Activation | Gene activation | LA638072 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS638072 | View Product |
| Gene knockdown (AAV) | VS638072 | View Product | |
| ORF Vector | Template DNA | PC638072 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |