PTGS2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use PTGS2-specific vectors and viral particles designed for reliable PTGS2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including PTGS2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human PTGS2 Gene Overview
| Gene Name | prostaglandin-endoperoxide synthase 2 |
|---|---|
| Gene Symbol | PTGS2 |
| Synonyms | COX2,COX-2,PHS-2,PGG/HS,PGHS-2,hCox-2,GRIPGHS |
| NCBI ID | 5743 |
| Ensembl ID | ENSG00000073756 |
| Uniprot ID | P35354 |
| Gene Type | Protein coding |
Gene Summary
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
Human PTGS2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC138103 | View Product |
| AAV Vector & Virus | Long-term expression | VC138103 | View Product |
| Adenovirus | Transient expression | A138103 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG138103 | View Product |
| Gene knockout (non-viral) | PG138103 | View Product | |
| Gene knockout (AAV) | VG138103 | View Product | |
| CRISPR Activation | Gene activation | LA138103 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS138103 | View Product |
| Gene knockdown (AAV) | VS138103 | View Product | |
| ORF Vector | Template DNA | PC138103 | View Product |
Mouse Ptgs2 Gene Overview
| Gene Name | prostaglandin-endoperoxide synthase 2 |
|---|---|
| Gene Symbol | Ptgs2 |
| Synonyms | COX2,Cox-2,PES-2,PHS-2,Pghs2,TIS10,PGHS-2,PHS II,gripghs |
| NCBI ID | 19225 |
| Ensembl ID | ENSMUSG00000032487 |
| Uniprot ID | Q05769 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes an enzyme that is a member of the prostaglandin G/H synthase family. The encoded protein converts arachidonic acid to prostaglandin endoperoxide H2 which is a key enzymatic step in prostaglandin biosynthesis. This gene is the inducible prostaglandin G/H synthase family member that is upregulated during inflammation. Aberrant regulation of this gene is associated with cancer progression in several tissues and an increased risk of cardiovascular events. This gene is the target of many non-steroidal anti-inflammatory drugs. [provided by RefSeq, Sep 2015]
Mouse Ptgs2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC438103 | View Product |
| AAV Vector & Virus | Long-term expression | VC438103 | View Product |
| Adenovirus | Transient expression | A438103 | View Product |
| ORF Vector | Template DNA | PC438103 | View Product |
Rat Ptgs2 Gene Overview
| Gene Name | prostaglandin-endoperoxide synthase 2 |
|---|---|
| Gene Symbol | Ptgs2 |
| Synonyms | Cox2,COX-2,Pghs2,PGHS-2,PHS II |
| NCBI ID | 29527 |
| Ensembl ID | ENSRNOG00000002525 |
| Uniprot ID | P35355 |
| Gene Type | Protein coding |
Gene Summary
Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and positive regulation of cytokine production. Acts upstream of or within bone mineralization. Located in caveola and cytoplasm. Part of protein-containing complex. Used to study several diseases, including brain disease (multiple); hypertension (multiple); liver disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including carcinoma (multiple); glioblastoma (multiple); inflammatory bowel disease (multiple); pleurisy; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); avian influenza; cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ptgs2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC638103 | View Product |
| AAV Vector & Virus | Long-term expression | VC638103 | View Product |
| Adenovirus | Transient expression | A638103 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG638103 | View Product |
| Gene knockout (non-viral) | PG638103 | View Product | |
| Gene knockout (AAV) | VG638103 | View Product | |
| CRISPR Activation | Gene activation | LA638103 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS638103 | View Product |
| Gene knockdown (AAV) | VS638103 | View Product | |
| ORF Vector | Template DNA | PC638103 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |