PTPN11 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use PTPN11-specific vectors and viral particles designed for reliable PTPN11 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including PTPN11 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human PTPN11 Gene Overview
| Gene Name | protein tyrosine phosphatase non-receptor type 11 |
|---|---|
| Gene Symbol | PTPN11 |
| Synonyms | CFC,NS1,JMML,SHP2,BPTP3,PTP2C,METCDS,PTP-1D,SH-PTP2,SH-PTP3 |
| NCBI ID | 5781 |
| Ensembl ID | ENSG00000179295 |
| Uniprot ID | Q06124 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
Human PTPN11 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC138147 | View Product |
| Stable overexpression | LC238147 | View Product | |
| AAV Vector & Virus | Long-term expression | VC138147 | View Product |
| Long-term expression | VC238147 | View Product | |
| Adenovirus | Transient expression | A238147 | View Product |
| Transient expression | A338147 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG138147 | View Product |
| Gene knockout (non-viral) | PG138147 | View Product | |
| Gene knockout (AAV) | VG138147 | View Product | |
| CRISPR Activation | Gene activation | LA138147 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS138147 | View Product |
| Gene knockdown (AAV) | VS138147 | View Product | |
| ORF Vector | Template DNA | PC138147 | View Product |
| Template DNA | PC238147 | View Product |
Mouse Ptpn11 Gene Overview
| Gene Name | protein tyrosine phosphatase, non-receptor type 11 |
|---|---|
| Gene Symbol | Ptpn11 |
| Synonyms | Syp,Shp2,PTP1D,PTP2C,SAP-2,SHP-2,SH-PTP2,SH-PTP3,2700084A17Rik |
| NCBI ID | 19247 |
| Ensembl ID | ENSMUSG00000043733 |
| Uniprot ID | P35235 |
| Gene Type | Protein coding |
Gene Summary
Enables cell adhesion molecule binding activity; non-membrane spanning protein tyrosine phosphatase activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of chondrocyte differentiation; positive regulation of cytokine production; and positive regulation of lipopolysaccharide-mediated signaling pathway. Acts upstream of or within several processes, including cell surface receptor signaling pathway; myeloid cell differentiation; and regulation of hormone secretion. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and retina. Used to study several diseases, including Noonan syndrome 1; hepatocellular adenoma; idiopathic scoliosis; intrinsic cardiomyopathy (multiple); and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Ptpn11 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC438147 | View Product |
| Stable overexpression | LC538147 | View Product | |
| AAV Vector & Virus | Long-term expression | VC438147 | View Product |
| Long-term expression | VC538147 | View Product | |
| Adenovirus | Transient expression | A438147 | View Product |
| Transient expression | A538147 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG438147 | View Product |
| Gene knockout (non-viral) | PG438147 | View Product | |
| Gene knockout (AAV) | VG438147 | View Product | |
| CRISPR Activation | Gene activation | LA438147 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS438147 | View Product |
| Gene knockdown (AAV) | VS438147 | View Product | |
| ORF Vector | Template DNA | PC438147 | View Product |
| Template DNA | PC538147 | View Product |
Rat Ptpn11 Gene Overview
| Gene Name | protein tyrosine phosphatase, non-receptor type 11 |
|---|---|
| Gene Symbol | Ptpn11 |
| Synonyms | Shp2 |
| NCBI ID | 25622 |
| Ensembl ID | ENSRNOG00000030124 |
| Uniprot ID | P41499 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including insulin receptor substrate binding activity; phospholipase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to peptide hormone stimulus; and positive regulation of focal adhesion assembly. Located in plasma membrane raft. Part of protein-containing complex. Used to study glaucoma. Biomarker of glaucoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ptpn11 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC638147 | View Product |
| Stable overexpression | LC738147 | View Product | |
| AAV Vector & Virus | Long-term expression | VC638147 | View Product |
| Long-term expression | VC738147 | View Product | |
| Adenovirus | Transient expression | A638147 | View Product |
| Transient expression | A738147 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG638147 | View Product |
| Gene knockout (non-viral) | PG638147 | View Product | |
| Gene knockout (AAV) | VG638147 | View Product | |
| CRISPR Activation | Gene activation | LA638147 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS638147 | View Product |
| Gene knockdown (AAV) | VS638147 | View Product | |
| ORF Vector | Template DNA | PC638147 | View Product |
| Template DNA | PC738147 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |