PTPRC Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use PTPRC-specific vectors and viral particles designed for reliable PTPRC overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including PTPRC CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human PTPRC Gene Overview
| Gene Name | protein tyrosine phosphatase receptor type C |
|---|---|
| Gene Symbol | PTPRC |
| Synonyms | LCA,LY5,B220,CD45,L-CA,T200,CD45R,GP180,IMD105 |
| NCBI ID | 5788 |
| Ensembl ID | ENSG00000081237 |
| Uniprot ID | P08575 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Human PTPRC Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC138170 | View Product |
| AAV Vector & Virus | Long-term expression | VC138170 | View Product |
| Adenovirus | Transient expression | A138170 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG138170 | View Product |
| Gene knockout (non-viral) | PG138170 | View Product | |
| Gene knockout (AAV) | VG138170 | View Product | |
| CRISPR Activation | Gene activation | LA138170 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS138170 | View Product |
| Gene knockdown (AAV) | VS138170 | View Product | |
| ORF Vector | Template DNA | PC138170 | View Product |
Mouse Ptprc Gene Overview
| Gene Name | protein tyrosine phosphatase receptor type C |
|---|---|
| Gene Symbol | Ptprc |
| Synonyms | loc,B220,Cd45,L-CA,Ly-5,T200,CD45R,Lyt-4 |
| NCBI ID | 19264 |
| Ensembl ID | ENSMUSG00000026395 |
| Uniprot ID | P06800 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including heparan sulfate proteoglycan binding activity; heparin binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including lymphocyte differentiation; regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within several processes, including T cell activation; positive regulation of lymphocyte activation; and regulation of protein phosphorylation. Located in external side of plasma membrane; focal adhesion; and membrane raft. Is expressed in several structures, including alimentary system; cardiovascular system; hemolymphoid system; placenta; and skin. Used to study Alzheimer's disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency 105. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Ptprc Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC438170 | View Product |
| Stable overexpression | LC538170 | View Product | |
| Adenovirus | Transient expression | A438170 | View Product |
| Transient expression | A538170 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG438170 | View Product |
| Gene knockout (non-viral) | PG438170 | View Product | |
| Gene knockout (AAV) | VG438170 | View Product | |
| CRISPR Activation | Gene activation | LA438170 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS438170 | View Product |
| Gene knockdown (AAV) | VS438170 | View Product | |
| ORF Vector | Template DNA | PC438170 | View Product |
| Template DNA | PC538170 | View Product |
Rat Ptprc Gene Overview
| Gene Name | protein tyrosine phosphatase, receptor type, C |
|---|---|
| Gene Symbol | Ptprc |
| Synonyms | Lca,RT7,CD45,L-CA,T200 |
| NCBI ID | 24699 |
| Ensembl ID | ENSRNOG00000000655 |
| Uniprot ID | P04157 |
| Gene Type | Protein coding |
Gene Summary
Enables protein tyrosine phosphatase activity. Involved in several processes, including T cell receptor signaling pathway; response to aldosterone; and response to gamma radiation. Located in cell surface and plasma membrane. Biomarker of hypertension and retinal degeneration. Human ortholog(s) of this gene implicated in multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency 105. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ptprc Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC638170 | View Product |
| Stable overexpression | LC738170 | View Product | |
| Adenovirus | Transient expression | A638170 | View Product |
| Transient expression | A738170 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG638170 | View Product |
| Gene knockout (non-viral) | PG638170 | View Product | |
| Gene knockout (AAV) | VG638170 | View Product | |
| CRISPR Activation | Gene activation | LA638170 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS638170 | View Product |
| Gene knockdown (AAV) | VS638170 | View Product | |
| ORF Vector | Template DNA | PC638170 | View Product |
| Template DNA | PC738170 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |