RB1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use RB1-specific vectors and viral particles designed for reliable RB1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including RB1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human RB1 Gene Overview
| Gene Name | RB transcriptional corepressor 1 |
|---|---|
| Gene Symbol | RB1 |
| Synonyms | RB,pRb,OSRC,pp110,p105-Rb,PPP1R130,p110-RB1 |
| NCBI ID | 5925 |
| Ensembl ID | ENSG00000139687 |
| Uniprot ID | P06400 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Human RB1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC138567 | View Product |
| AAV Vector & Virus | Long-term expression | VC138567 | View Product |
| Adenovirus | Transient expression | A138567 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG138567 | View Product |
| Gene knockout (non-viral) | PG138567 | View Product | |
| Gene knockout (AAV) | VG138567 | View Product | |
| CRISPR Activation | Gene activation | LA138567 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS138567 | View Product |
| Gene knockdown (AAV) | VS138567 | View Product | |
| ORF Vector | Template DNA | PC138567 | View Product |
Mouse Rb1 Gene Overview
| Gene Name | RB transcriptional corepressor 1 |
|---|---|
| Gene Symbol | Rb1 |
| Synonyms | Rb,pRb,Rb-1,pp105,p110-RB1 |
| NCBI ID | 19645 |
| Ensembl ID | ENSMUSG00000022105 |
| Uniprot ID | P13405 |
| Gene Type | Protein coding |
Gene Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and enzyme binding activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; negative regulation of myofibroblast differentiation; and positive regulation of collagen fibril organization. Acts upstream of or within several processes, including negative regulation of cell population proliferation; neuron development; and regulation of transcription by RNA polymerase II. Located in cytoplasm; nucleus; and spindle. Part of Rb-E2F complex. Is expressed in several structures, including alimentary system; central nervous system; eye; gonad; and integumental system. Used to study lung small cell carcinoma; osteosarcoma; retinoblastoma; and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including high grade glioma (multiple); osteosarcoma; prostate cancer; retinoblastoma (multiple); and small cell carcinoma. Orthologous to human RB1 (RB transcriptional corepressor 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Rb1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC438567 | View Product |
| AAV Vector & Virus | Long-term expression | VC438567 | View Product |
| Adenovirus | Transient expression | A438567 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG438567 | View Product |
| Gene knockout (non-viral) | PG438567 | View Product | |
| Gene knockout (AAV) | VG438567 | View Product | |
| CRISPR Activation | Gene activation | LA438567 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS438567 | View Product |
| Gene knockdown (AAV) | VS438567 | View Product | |
| ORF Vector | Template DNA | PC438567 | View Product |
Rat Rb1 Gene Overview
| Gene Name | RB transcriptional corepressor 1 |
|---|---|
| Gene Symbol | Rb1 |
| Synonyms | |
| NCBI ID | 24708 |
| Ensembl ID | ENSRNOG00000016029 |
| Uniprot ID | P33568 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including disordered domain specific binding activity; enzyme binding activity; and importin-alpha family protein binding activity. Involved in negative regulation of apoptotic process; negative regulation of cell cycle; and spermatogenesis. Predicted to be located in PML body; cytoplasm; and spindle. Predicted to be part of Rb-E2F complex; chromatin lock complex; and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in chromatin. Biomarker of acute kidney failure and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including high grade glioma (multiple); osteosarcoma; prostate cancer; retinoblastoma (multiple); and small cell carcinoma. Orthologous to human RB1 (RB transcriptional corepressor 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Rb1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC638567 | View Product |
| AAV Vector & Virus | Long-term expression | VC638567 | View Product |
| Adenovirus | Transient expression | A638567 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG638567 | View Product |
| Gene knockout (non-viral) | PG638567 | View Product | |
| Gene knockout (AAV) | VG638567 | View Product | |
| CRISPR Activation | Gene activation | LA638567 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS638567 | View Product |
| Gene knockdown (AAV) | VS638567 | View Product | |
| ORF Vector | Template DNA | PC638567 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |