RELA Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use RELA-specific vectors and viral particles designed for reliable RELA overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including RELA CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human RELA Gene Overview
| Gene Name | RELA proto-oncogene, NF-kB subunit |
|---|---|
| Gene Symbol | RELA |
| Synonyms | p65,CMCU,NFKB3,AIF3BL3 |
| NCBI ID | 5970 |
| Ensembl ID | ENSG00000173039 |
| Uniprot ID | Q04206 |
| Gene Type | Protein coding |
Gene Summary
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Human RELA Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Mouse Rela Gene Overview
| Gene Name | Rela proto-oncogene, NFKB subunit |
|---|---|
| Gene Symbol | Rela |
| Synonyms | p65,p65 NFkB,p65 NF-kappa B |
| NCBI ID | 19697 |
| Ensembl ID | ENSMUSG00000024927 |
| Uniprot ID | Q04207 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; actinin binding activity; and ankyrin repeat binding activity. Involved in several processes, including negative regulation of protein sumoylation; positive regulation of canonical NF-kappaB signal transduction; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; negative regulation of extrinsic apoptotic signaling pathway; and positive regulation of interleukin-12 production. Located in chromatin; cytosol; and nucleus. Part of NF-kappaB p50/p65 complex and transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; musculature; and skin. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Rela Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC438802 | View Product |
| AAV Vector & Virus | Long-term expression | VC438802 | View Product |
| Adenovirus | Transient expression | A438802 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG438802 | View Product |
| Gene knockout (non-viral) | PG438802 | View Product | |
| Gene knockout (AAV) | VG438802 | View Product | |
| CRISPR Activation | Gene activation | LA438802 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS438802 | View Product |
| Gene knockdown (AAV) | VS438802 | View Product | |
| ORF Vector | Template DNA | PC438802 | View Product |
Rat Rela Gene Overview
| Gene Name | RELA proto-oncogene, NF-kB subunit |
|---|---|
| Gene Symbol | Rela |
| Synonyms | NFkB,nos2 |
| NCBI ID | 309165 |
| Ensembl ID | ENSRNOG00000030888 |
| Uniprot ID | Q7TQN4 |
| Gene Type | Protein coding |
Gene Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of Schwann cell differentiation; positive regulation of miRNA transcription; and response to ischemia. Located in chromatin; cytoplasm; and nucleus. Part of protein-containing complex. Is active in synapse. Used to study Parkinsonism; encephalitis; status epilepticus; and steatotic liver disease. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); colitis; end stage renal disease; and liver disease (multiple). Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Jul 2025]
Rat Rela Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC638802 | View Product |
| AAV Vector & Virus | Long-term expression | VC638802 | View Product |
| Adenovirus | Transient expression | A638802 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG638802 | View Product |
| Gene knockout (non-viral) | PG638802 | View Product | |
| Gene knockout (AAV) | VG638802 | View Product | |
| CRISPR Activation | Gene activation | LA638802 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS638802 | View Product |
| Gene knockdown (AAV) | VS638802 | View Product | |
| ORF Vector | Template DNA | PC638802 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |