RHOA Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use RHOA-specific vectors and viral particles designed for reliable RHOA overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including RHOA CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human RHOA Gene Overview
| Gene Name | ras homolog family member A |
|---|---|
| Gene Symbol | RHOA |
| Synonyms | ARHA,ARH12,RHO12,EDFAOB,RHOH12 |
| NCBI ID | 387 |
| Ensembl ID | ENSG00000067560 |
| Uniprot ID | P61586 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
Human RHOA Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC139509 | View Product |
| AAV Vector & Virus | Long-term expression | VC139509 | View Product |
| Adenovirus | Transient expression | A139509 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG139509 | View Product |
| Gene knockout (non-viral) | PG139509 | View Product | |
| Gene knockout (AAV) | VG139509 | View Product | |
| CRISPR Activation | Gene activation | LA139509 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS139509 | View Product |
| Gene knockdown (AAV) | VS139509 | View Product | |
| ORF Vector | Template DNA | PC139509 | View Product |
Mouse Rhoa Gene Overview
| Gene Name | ras homolog family member A |
|---|---|
| Gene Symbol | Rhoa |
| Synonyms | Arha,Arha1,Arha2 |
| NCBI ID | 11848 |
| Ensembl ID | ENSMUSG00000007815 |
| Uniprot ID | Q9QUI0 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
Mouse Rhoa Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC439509 | View Product |
| AAV Vector & Virus | Long-term expression | VC439509 | View Product |
| Adenovirus | Transient expression | A439509 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG439509 | View Product |
| Gene knockout (non-viral) | PG439509 | View Product | |
| Gene knockout (AAV) | VG439509 | View Product | |
| CRISPR Activation | Gene activation | LA439509 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS439509 | View Product |
| Gene knockdown (AAV) | VS439509 | View Product | |
| ORF Vector | Template DNA | PC439509 | View Product |
Rat Rhoa Gene Overview
| Gene Name | ras homolog family member A |
|---|---|
| Gene Symbol | Rhoa |
| Synonyms | Arha,Arha2 |
| NCBI ID | 117273 |
| Ensembl ID | ENSRNOG00000050519 |
| Uniprot ID | P61589 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including GTPase activity; Rho GDP-dissociation inhibitor binding activity; and guanyl ribonucleotide binding activity. Involved in several processes, including negative regulation of canonical NF-kappaB signal transduction; positive regulation of actin filament polymerization; and regulation of neuron projection development. Acts upstream of or within Rho protein signal transduction; negative regulation of vascular associated smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Located in several cellular components, including axon; dendritic spine; and neuronal cell body. Used to study membranous glomerulonephritis. Biomarker of artery disease (multiple); asthma; fetal alcohol syndrome; obesity; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A). [provided by Alliance of Genome Resources, Jul 2025]
Rat Rhoa Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC639509 | View Product |
| AAV Vector & Virus | Long-term expression | VC639509 | View Product |
| Adenovirus | Transient expression | A639509 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG639509 | View Product |
| Gene knockout (non-viral) | PG639509 | View Product | |
| Gene knockout (AAV) | VG639509 | View Product | |
| CRISPR Activation | Gene activation | LA639509 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS639509 | View Product |
| Gene knockdown (AAV) | VS639509 | View Product | |
| ORF Vector | Template DNA | PC639509 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |