RIPK1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use RIPK1-specific vectors and viral particles designed for reliable RIPK1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including RIPK1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human RIPK1 Gene Overview
| Gene Name | receptor interacting serine/threonine kinase 1 |
|---|---|
| Gene Symbol | RIPK1 |
| Synonyms | RIP,RIP1,AIEFL,IMD57,RIP-1 |
| NCBI ID | 8737 |
| Ensembl ID | ENSG00000137275 |
| Uniprot ID | Q13546 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]
Human RIPK1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC139610 | View Product |
| AAV Vector & Virus | Long-term expression | VC139610 | View Product |
| Adenovirus | Transient expression | A139610 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG139610 | View Product |
| Gene knockout (non-viral) | PG139610 | View Product | |
| Gene knockout (AAV) | VG139610 | View Product | |
| CRISPR Activation | Gene activation | LA139610 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS139610 | View Product |
| Gene knockdown (AAV) | VS139610 | View Product | |
| ORF Vector | Template DNA | PC139610 | View Product |
Mouse Ripk1 Gene Overview
| Gene Name | receptor (TNFRSF)-interacting serine-threonine kinase 1 |
|---|---|
| Gene Symbol | Ripk1 |
| Synonyms | RIP,Rinp,Rip1,RIP-1,D330015H01Rik |
| NCBI ID | 19766 |
| Ensembl ID | ENSMUSG00000021408 |
| Uniprot ID | Q60855 |
| Gene Type | Protein coding |
Gene Summary
Enables protein homodimerization activity; protein serine/threonine kinase activity; and signaling adaptor activity. Involved in several processes, including necroptotic signaling pathway; negative regulation of necroptotic process; and regulation of signal transduction. Acts upstream of or within several processes, including negative regulation of canonical NF-kappaB signal transduction; regulation of extrinsic apoptotic signaling pathway; and ripoptosome assembly involved in necroptotic process. Predicted to be located in mitochondrion. Predicted to be part of death-inducing signaling complex; receptor complex; and ripoptosome. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; immune system; limb; liver; and lung. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Ripk1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC439610 | View Product |
| AAV Vector & Virus | Long-term expression | VC439610 | View Product |
| Adenovirus | Transient expression | A439610 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG439610 | View Product |
| Gene knockout (non-viral) | PG439610 | View Product | |
| Gene knockout (AAV) | VG439610 | View Product | |
| CRISPR Activation | Gene activation | LA439610 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS439610 | View Product |
| Gene knockdown (AAV) | VS439610 | View Product | |
| ORF Vector | Template DNA | PC439610 | View Product |
Rat Ripk1 Gene Overview
| Gene Name | receptor interacting serine/threonine kinase 1 |
|---|---|
| Gene Symbol | Ripk1 |
| Synonyms | |
| NCBI ID | 306886 |
| Ensembl ID | ENSRNOG00000017787 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Enables death receptor binding activity. Involved in positive regulation of necroptotic process; positive regulation of neuron apoptotic process; and positive regulation of non-canonical NF-kappaB signal transduction. Part of protein-containing complex. Used to study epilepsy. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ripk1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC639610 | View Product |
| AAV Vector & Virus | Long-term expression | VC639610 | View Product |
| Adenovirus | Transient expression | A639610 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG639610 | View Product |
| Gene knockout (non-viral) | PG639610 | View Product | |
| Gene knockout (AAV) | VG639610 | View Product | |
| CRISPR Activation | Gene activation | LA639610 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS639610 | View Product |
| Gene knockdown (AAV) | VS639610 | View Product | |
| ORF Vector | Template DNA | PC639610 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |