RUNX2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use RUNX2-specific vectors and viral particles designed for reliable RUNX2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including RUNX2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human RUNX2 Gene Overview
| Gene Name | RUNX family transcription factor 2 |
|---|---|
| Gene Symbol | RUNX2 |
| Synonyms | CCD,AML3,CCD1,CLCD,OSF2,CBFA1,OSF-2,PEA2aA,PEBP2aA,CBF-alpha-1 |
| NCBI ID | 860 |
| Ensembl ID | ENSG00000124813 |
| Uniprot ID | Q13950 |
| Gene Type | Protein coding |
Gene Summary
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]
Human RUNX2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC141831 | View Product |
| AAV Vector & Virus | Long-term expression | VC141831 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG142890 | View Product |
| Gene knockout (non-viral) | PG142890 | View Product | |
| Gene knockout (AAV) | VG142890 | View Product | |
| CRISPR Activation | Gene activation | LA142890 | View Product |
| siRNA Tools | Gene knockdown (AAV) | VS142890 | View Product |
| ORF Vector | Template DNA | PC141831 | View Product |
Mouse Runx2 Gene Overview
| Gene Name | runt related transcription factor 2 |
|---|---|
| Gene Symbol | Runx2 |
| Synonyms | Cbf,LS3,AML3,Osf2,Cbfa1,Cbfa-1,PEBP2aA,Pebp2a1,Pebpa2a,CBF-alpha-1 |
| NCBI ID | 12393 |
| Ensembl ID | ENSMUSG00000039153 |
| Uniprot ID | Q08775 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the runt domain-containing family of transcription factors. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Sep 2015]
Mouse Runx2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC442890 | View Product |
| Stable overexpression | LC542890 | View Product | |
| AAV Vector & Virus | Long-term expression | VC442890 | View Product |
| Long-term expression | VC542890 | View Product | |
| Adenovirus | Transient expression | A442890 | View Product |
| Transient expression | A542890 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG442890 | View Product |
| Gene knockout (non-viral) | PG442890 | View Product | |
| Gene knockout (AAV) | VG442890 | View Product | |
| CRISPR Activation | Gene activation | LA442890 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS442890 | View Product |
| Gene knockdown (AAV) | VS442890 | View Product | |
| ORF Vector | Template DNA | PC442890 | View Product |
| Template DNA | PC542890 | View Product |
Rat Runx2 Gene Overview
| Gene Name | RUNX family transcription factor 2 |
|---|---|
| Gene Symbol | Runx2 |
| Synonyms | Cbfa1,OSF-2,CBF-alpha-1 |
| NCBI ID | 367218 |
| Ensembl ID | ENSRNOG00000020193 |
| Uniprot ID | Q9Z2J9 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA-binding transcription factor binding activity; general transcription initiation factor binding activity; and histone deacetylase binding activity. Involved in several processes, including cellular response to zinc ion starvation; positive regulation of ossification; and response to insulin. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in cleidocranial dysplasia; lung non-small cell carcinoma; and metaphyseal dysplasia-maxillary hypoplasia-brachydactyly syndrome. Orthologous to human RUNX2 (RUNX family transcription factor 2). [provided by Alliance of Genome Resources, Apr 2025]
Rat Runx2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC642890 | View Product |
| AAV Vector & Virus | Long-term expression | VC642890 | View Product |
| Adenovirus | Transient expression | A642890 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG642890 | View Product |
| Gene knockout (non-viral) | PG642890 | View Product | |
| Gene knockout (AAV) | VG642890 | View Product | |
| CRISPR Activation | Gene activation | LA642890 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS642890 | View Product |
| Gene knockdown (AAV) | VS642890 | View Product | |
| ORF Vector | Template DNA | PC642890 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |