SDHD Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SDHD-specific vectors and viral particles designed for reliable SDHD overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SDHD CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SDHD Gene Overview
| Gene Name | succinate dehydrogenase complex subunit D |
|---|---|
| Gene Symbol | SDHD |
| Synonyms | PGL,CBT1,CWS3,PGL1,QPs3,SDH4,cybS,CII-4,PPGL1,MC2DN3 |
| NCBI ID | 6392 |
| Ensembl ID | ENSG00000204370 |
| Uniprot ID | O14521 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Human SDHD Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC243257 | View Product |
| AAV Vector & Virus | Long-term expression | VC143257 | View Product |
| Adenovirus | Transient expression | A143257 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG143257 | View Product |
| Gene knockout (non-viral) | PG143257 | View Product | |
| Gene knockout (AAV) | VG143257 | View Product | |
| CRISPR Activation | Gene activation | LA143257 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS143257 | View Product |
| Gene knockdown (AAV) | VS143257 | View Product | |
| ORF Vector | Template DNA | PC143257 | View Product |
Mouse Sdhd Gene Overview
| Gene Name | succinate dehydrogenase complex, subunit D, integral membrane protein |
|---|---|
| Gene Symbol | Sdhd |
| Synonyms | QPs3,cybS,CII-4,AVLL5809,PRO19626,3110001M13Rik |
| NCBI ID | 66925 |
| Ensembl ID | ENSMUSG00000000171 |
| Uniprot ID | Q9CXV1 |
| Gene Type | Protein coding |
Gene Summary
Enables succinate dehydrogenase (quinone) activity. Acts upstream of or within cellular response to hypoxia and regulation of catecholamine secretion. Located in mitochondrion. Part of respiratory chain complex II (succinate dehydrogenase). Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHD (succinate dehydrogenase complex subunit D). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Sdhd Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC443257 | View Product |
| AAV Vector & Virus | Long-term expression | VC443257 | View Product |
| Adenovirus | Transient expression | A443257 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG443257 | View Product |
| Gene knockout (non-viral) | PG443257 | View Product | |
| Gene knockout (AAV) | VG443257 | View Product | |
| CRISPR Activation | Gene activation | LA443257 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS443257 | View Product |
| Gene knockdown (AAV) | VS443257 | View Product | |
| ORF Vector | Template DNA | PC443257 | View Product |
Rat Sdhd Gene Overview
| Gene Name | succinate dehydrogenase complex subunit D |
|---|---|
| Gene Symbol | Sdhd |
| Synonyms | QPs3,cybS,CII-4 |
| NCBI ID | 363061 |
| Ensembl ID | ENSRNOG00000022980 |
| Uniprot ID | Q6PCT8 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including heme binding activity; succinate dehydrogenase (quinone) activity; and ubiquinone binding activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone and tricarboxylic acid cycle. Predicted to act upstream of or within cellular response to hypoxia and regulation of catecholamine secretion. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHD (succinate dehydrogenase complex subunit D). [provided by Alliance of Genome Resources, Jul 2025]
Rat Sdhd Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC643257 | View Product |
| AAV Vector & Virus | Long-term expression | VC643257 | View Product |
| Adenovirus | Transient expression | A643257 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG643257 | View Product |
| Gene knockout (non-viral) | PG643257 | View Product | |
| Gene knockout (AAV) | VG643257 | View Product | |
| CRISPR Activation | Gene activation | LA643257 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS643257 | View Product |
| Gene knockdown (AAV) | VS643257 | View Product | |
| ORF Vector | Template DNA | PC643257 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |