SIRPA Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SIRPA-specific vectors and viral particles designed for reliable SIRPA overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SIRPA CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SIRPA Gene Overview
| Gene Name | signal regulatory protein alpha |
|---|---|
| Gene Symbol | SIRPA |
| Synonyms | BIT,MFR,P84,MYD1,SIRP,MYD-1,SHPS1,CD172A,PTPNS1 |
| NCBI ID | 140885 |
| Ensembl ID | ENSG00000198053 |
| Uniprot ID | P78324 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
Human SIRPA Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC130514 | View Product |
| Stable overexpression | LC143798 | View Product | |
| AAV Vector & Virus | Long-term expression | VC130514 | View Product |
| Long-term expression | VC143798 | View Product | |
| Adenovirus | Transient expression | A130514 | View Product |
| Transient expression | A143798 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG143798 | View Product |
| Gene knockout (non-viral) | PG143798 | View Product | |
| Gene knockout (AAV) | VG143798 | View Product | |
| CRISPR Activation | Gene activation | LA143798 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS143798 | View Product |
| Gene knockdown (AAV) | VS143798 | View Product | |
| ORF Vector | Template DNA | PC130514 | View Product |
| Template DNA | PC143798 | View Product |
Mouse Sirpa Gene Overview
| Gene Name | signal-regulatory protein alpha |
|---|---|
| Gene Symbol | Sirpa |
| Synonyms | Bit,P84,SIRP,SHP-1,CD172a,Ptpns1,SHPS-1,Idd13.2 |
| NCBI ID | 19261 |
| Ensembl ID | ENSMUSG00000037902 |
| Uniprot ID | P97797 |
| Gene Type | Protein coding |
Gene Summary
Enables protein phosphatase binding activity; protein phosphatase inhibitor activity; and protein phosphorylated amino acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of nitric oxide biosynthetic process; and negative regulation of signal transduction. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; phagocytosis; and positive regulation of phagocytosis. Located in plasma membrane. Is expressed in several structures, including adrenal gland; cartilage; central nervous system; genitourinary system; and retina. Orthologous to human SIRPA (signal regulatory protein alpha). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Sirpa Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC443798 | View Product |
| Stable overexpression | LC543798 | View Product | |
| AAV Vector & Virus | Long-term expression | VC443798 | View Product |
| Adenovirus | Transient expression | A443798 | View Product |
| Transient expression | A543798 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG443798 | View Product |
| Gene knockout (non-viral) | PG443798 | View Product | |
| Gene knockout (AAV) | VG443798 | View Product | |
| CRISPR Activation | Gene activation | LA443798 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS443798 | View Product |
| Gene knockdown (AAV) | VS443798 | View Product | |
| ORF Vector | Template DNA | PC443798 | View Product |
| Template DNA | PC543798 | View Product |
Rat Sirpa Gene Overview
| Gene Name | signal-regulatory protein alpha |
|---|---|
| Gene Symbol | Sirpa |
| Synonyms | Bit,Ptpns1,SHPS-1 |
| NCBI ID | 25528 |
| Ensembl ID | ENSRNOG00000004763 |
| Uniprot ID | P97710 |
| Gene Type | Protein coding |
Gene Summary
Enables GTPase regulator activity; enzyme binding activity; and protein binding activity involved in heterotypic cell-cell adhesion. Involved in several processes, including cellular response to cytokine stimulus; monocyte extravasation; and regulation of cytokine production. Located in cell surface. Orthologous to several human genes including SIRPA (signal regulatory protein alpha). [provided by Alliance of Genome Resources, Jul 2025]
Rat Sirpa Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC643798 | View Product |
| AAV Vector & Virus | Long-term expression | VC643798 | View Product |
| Adenovirus | Transient expression | A643798 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG643798 | View Product |
| Gene knockout (non-viral) | PG643798 | View Product | |
| Gene knockout (AAV) | VG643798 | View Product | |
| CRISPR Activation | Gene activation | LA643798 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS643798 | View Product |
| Gene knockdown (AAV) | VS643798 | View Product | |
| ORF Vector | Template DNA | PC643798 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |