SIRT1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SIRT1-specific vectors and viral particles designed for reliable SIRT1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SIRT1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SIRT1 Gene Overview
| Gene Name | sirtuin 1 |
|---|---|
| Gene Symbol | SIRT1 |
| Synonyms | SIR2,SIR2L1,SIR2alpha |
| NCBI ID | 23411 |
| Ensembl ID | ENSG00000096717 |
| Uniprot ID | Q96EB6 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Human SIRT1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC143806 | View Product |
| AAV Vector & Virus | Long-term expression | VC143806 | View Product |
| Adenovirus | Transient expression | A143806 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG143806 | View Product |
| Gene knockout (non-viral) | PG143806 | View Product | |
| Gene knockout (AAV) | VG143806 | View Product | |
| CRISPR Activation | Gene activation | LA143806 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS143806 | View Product |
| Gene knockdown (AAV) | VS143806 | View Product | |
| ORF Vector | Template DNA | PC143806 | View Product |
Mouse Sirt1 Gene Overview
| Gene Name | sirtuin 1 |
|---|---|
| Gene Symbol | Sirt1 |
| Synonyms | Sir2,Sir2a,SIR2L1,Sir2alpha |
| NCBI ID | 93759 |
| Ensembl ID | ENSMUSG00000020063 |
| Uniprot ID | Q923E4 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the sirtuin family of proteins, characterized by their deacetylase activity and proposed role in longevity. The encoded protein regulates gene expression in a wide range of cell and tissue types through its NAD+-dependent deacetylation of histones, transcription factors and transcriptional coactivators. Brain-specific overexpression of this gene has been shown to result in increased median lifespan. Viability of homozygous knockout mice for this gene varies with strain background. Homozygous knockout mice of strains that do not exhibit embryonic lethality are sterile and have a reduced lifespan. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Mouse Sirt1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC443806 | View Product |
| Stable overexpression | LC543806 | View Product | |
| AAV Vector & Virus | Long-term expression | VC443806 | View Product |
| Long-term expression | VC543806 | View Product | |
| Adenovirus | Transient expression | A443806 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG443806 | View Product |
| Gene knockout (non-viral) | PG443806 | View Product | |
| Gene knockout (AAV) | VG443806 | View Product | |
| CRISPR Activation | Gene activation | LA443806 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS443806 | View Product |
| Gene knockdown (AAV) | VS443806 | View Product | |
| ORF Vector | Template DNA | PC443806 | View Product |
| Template DNA | PC543806 | View Product |
Rat Sirt1 Gene Overview
| Gene Name | sirtuin 1 |
|---|---|
| Gene Symbol | Sirt1 |
| Synonyms | Sir2 |
| NCBI ID | 309757 |
| Ensembl ID | ENSRNOG00000051592 |
| Uniprot ID | A0A0G2JZ79 |
| Gene Type | Protein coding |
Gene Summary
Enables histone deacetylase activity, NAD-dependent and protein kinase B binding activity. Involved in several processes, including cellular response to ketone; negative regulation of apoptotic process; and regulation of peptide hormone secretion. Located in growth cone and nucleus. Used to study middle cerebral artery infarction; obesity; osteoporosis; and type 2 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); cocaine dependence; impotence; metabolic dysfunction-associated steatotic liver disease; and obesity. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Sirt1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |