SIRT2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SIRT2-specific vectors and viral particles designed for reliable SIRT2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SIRT2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SIRT2 Gene Overview
| Gene Name | sirtuin 2 |
|---|---|
| Gene Symbol | SIRT2 |
| Synonyms | SIR2,SIR2L,SIR2L2 |
| NCBI ID | 22933 |
| Ensembl ID | ENSG00000068903 |
| Uniprot ID | Q8IXJ6 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Human SIRT2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC143807 | View Product |
| AAV Vector & Virus | Long-term expression | VC143807 | View Product |
| Adenovirus | Transient expression | A143807 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG143807 | View Product |
| Gene knockout (non-viral) | PG143807 | View Product | |
| Gene knockout (AAV) | VG143807 | View Product | |
| CRISPR Activation | Gene activation | LA143807 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS143807 | View Product |
| Gene knockdown (AAV) | VS143807 | View Product | |
| ORF Vector | Template DNA | PC143807 | View Product |
Mouse Sirt2 Gene Overview
| Gene Name | sirtuin 2 |
|---|---|
| Gene Symbol | Sirt2 |
| Synonyms | Sir2l,SIR2L2,5730427M03Rik |
| NCBI ID | 64383 |
| Ensembl ID | ENSMUSG00000015149 |
| Uniprot ID | Q8VDQ8 |
| Gene Type | Protein coding |
Gene Summary
Enables NAD-dependent protein lysine deacetylase activity; histone deacetylase activity; and tubulin deacetylase activity. Involved in several processes, including cellular response to caloric restriction; positive regulation of cell cycle process; and regulation of macromolecule metabolic process. Acts upstream of or within several processes, including negative regulation of NLRP3 inflammasome complex assembly; regulation of fat cell differentiation; and tubulin deacetylation. Located in several cellular components, including Schmidt-Lanterman incisure; paranodal junction; and perikaryon. Is expressed in several structures, including brain; liver; oocyte; sensory organ; and spinal cord. Orthologous to human SIRT2 (sirtuin 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Sirt2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC443807 | View Product |
| Stable overexpression | LC543807 | View Product | |
| AAV Vector & Virus | Long-term expression | VC443807 | View Product |
| Long-term expression | VC543807 | View Product | |
| Adenovirus | Transient expression | A443807 | View Product |
| Transient expression | A543807 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG443807 | View Product |
| Gene knockout (non-viral) | PG443807 | View Product | |
| Gene knockout (AAV) | VG443807 | View Product | |
| CRISPR Activation | Gene activation | LA443807 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS443807 | View Product |
| Gene knockdown (AAV) | VS443807 | View Product | |
| ORF Vector | Template DNA | PC443807 | View Product |
| Template DNA | PC543807 | View Product |
Rat Sirt2 Gene Overview
| Gene Name | sirtuin 2 |
|---|---|
| Gene Symbol | Sirt2 |
| Synonyms | |
| NCBI ID | 361532 |
| Ensembl ID | ENSRNOG00000020102 |
| Uniprot ID | Q5RJQ4 |
| Gene Type | Protein coding |
Gene Summary
Enables NAD-dependent protein lysine deacetylase activity and tubulin deacetylase activity. Involved in several processes, including regulation of nervous system development; regulation of postsynaptic neurotransmitter receptor internalization; and tubulin deacetylation. Located in several cellular components, including Schmidt-Lanterman incisure; lateral loop; and main axon. Is active in glutamatergic synapse. Used to study high grade glioma and metabolic dysfunction-associated steatotic liver disease. Biomarker of cocaine dependence and intermittent claudication. Orthologous to human SIRT2 (sirtuin 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Sirt2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC643807 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG643807 | View Product |
| Gene knockout (non-viral) | PG643807 | View Product | |
| Gene knockout (AAV) | VG643807 | View Product | |
| CRISPR Activation | Gene activation | LA643807 | View Product |
| siRNA Tools | Gene knockdown (AAV) | VS643807 | View Product |
| ORF Vector | Template DNA | PC643807 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |