SIRT3 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SIRT3-specific vectors and viral particles designed for reliable SIRT3 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SIRT3 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SIRT3 Gene Overview
| Gene Name | sirtuin 3 |
|---|---|
| Gene Symbol | SIRT3 |
| Synonyms | SIR2L3 |
| NCBI ID | 23410 |
| Ensembl ID | ENSG00000142082 |
| Uniprot ID | Q9NTG7 |
| Gene Type | Protein coding |
Gene Summary
SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]
Human SIRT3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC130520 | View Product |
| Stable overexpression | LC143808 | View Product | |
| AAV Vector & Virus | Long-term expression | VC130520 | View Product |
| Long-term expression | VC143808 | View Product | |
| Adenovirus | Transient expression | A130520 | View Product |
| Transient expression | A143808 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG143808 | View Product |
| Gene knockout (non-viral) | PG143808 | View Product | |
| Gene knockout (AAV) | VG143808 | View Product | |
| CRISPR Activation | Gene activation | LA143808 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS143808 | View Product |
| Gene knockdown (AAV) | VS143808 | View Product | |
| ORF Vector | Template DNA | PC130520 | View Product |
| Template DNA | PC143808 | View Product |
Mouse Sirt3 Gene Overview
| Gene Name | sirtuin 3 |
|---|---|
| Gene Symbol | Sirt3 |
| Synonyms | Sir2l3,2310003L23Rik |
| NCBI ID | 64384 |
| Ensembl ID | ENSMUSG00000025486 |
| Uniprot ID | Q8R104 |
| Gene Type | Protein coding |
Gene Summary
Enables NAD-dependent protein lysine deacetylase activity; protein lysine deacetylase activity; and sequence-specific DNA binding activity. Involved in peptidyl-lysine deacetylation; positive regulation of ceramide biosynthetic process; and positive regulation of mitochondrial transcription. Acts upstream of or within negative regulation of peptidyl-lysine acetylation; protein deacetylation; and tricarboxylic acid cycle. Located in mitochondrial inner membrane and mitochondrial matrix. Part of protein-containing complex. Is expressed in several structures, including brain; branchial arch; endocrine gland; genitourinary system; and liver and biliary system. Used to study abdominal obesity-metabolic syndrome. Orthologous to human SIRT3 (sirtuin 3). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Sirt3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC443808 | View Product |
| Stable overexpression | LC543808 | View Product | |
| AAV Vector & Virus | Long-term expression | VC443808 | View Product |
| Adenovirus | Transient expression | A443808 | View Product |
| Transient expression | A543808 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG443808 | View Product |
| Gene knockout (non-viral) | PG443808 | View Product | |
| Gene knockout (AAV) | VG443808 | View Product | |
| CRISPR Activation | Gene activation | LA443808 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS443808 | View Product |
| Gene knockdown (AAV) | VS443808 | View Product | |
| ORF Vector | Template DNA | PC443808 | View Product |
| Template DNA | PC543808 | View Product |
Rat Sirt3 Gene Overview
| Gene Name | sirtuin 3 |
|---|---|
| Gene Symbol | Sirt3 |
| Synonyms | |
| NCBI ID | 293615 |
| Ensembl ID | ENSRNOG00000013828 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Enables enzyme binding activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of reactive oxygen species metabolic process; and positive regulation of insulin secretion. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion and nucleus. Used to study metabolic dysfunction-associated steatotic liver disease. Biomarker of congestive heart failure; myocardial infarction; obesity; and prediabetes syndrome. Orthologous to human SIRT3 (sirtuin 3). [provided by Alliance of Genome Resources, Jul 2025]
Rat Sirt3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC643808 | View Product |
| AAV Vector & Virus | Long-term expression | VC643808 | View Product |
| Adenovirus | Transient expression | A643808 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG643808 | View Product |
| Gene knockout (non-viral) | PG643808 | View Product | |
| Gene knockout (AAV) | VG643808 | View Product | |
| CRISPR Activation | Gene activation | LA643808 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS643808 | View Product |
| Gene knockdown (AAV) | VS643808 | View Product | |
| ORF Vector | Template DNA | PC643808 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |