SIRT6 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SIRT6-specific vectors and viral particles designed for reliable SIRT6 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SIRT6 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SIRT6 Gene Overview
| Gene Name | sirtuin 6 |
|---|---|
| Gene Symbol | SIRT6 |
| Synonyms | SIR2L6,hSIRT6 |
| NCBI ID | 51548 |
| Ensembl ID | ENSG00000077463 |
| Uniprot ID | Q8N6T7 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Human SIRT6 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC143811 | View Product |
| Stable overexpression | LC343811 | View Product | |
| AAV Vector & Virus | Long-term expression | VC143811 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG143811 | View Product |
| Gene knockout (non-viral) | PG143811 | View Product | |
| Gene knockout (AAV) | VG143811 | View Product | |
| CRISPR Activation | Gene activation | LA143811 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS143811 | View Product |
| Gene knockdown (AAV) | VS143811 | View Product | |
| ORF Vector | Template DNA | PC143811 | View Product |
| Template DNA | PC343811 | View Product |
Mouse Sirt6 Gene Overview
| Gene Name | sirtuin 6 |
|---|---|
| Gene Symbol | Sirt6 |
| Synonyms | Sir2l6,mSIRT6,2810449N18Rik |
| NCBI ID | 50721 |
| Ensembl ID | ENSMUSG00000034748 |
| Uniprot ID | P59941 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including NAD+-protein-arginine ADP-ribosyltransferase activity; TORC2 complex binding activity; and histone deacetylase activity, NAD-dependent. Involved in several processes, including chromatin remodeling; regulation of nucleobase-containing compound metabolic process; and regulation of protein localization. Located in nucleus. Is active in chromatin. Is expressed in several structures, including alimentary system; central nervous system; gonad; musculature; and retina. Used to study progeria. Orthologous to human SIRT6 (sirtuin 6). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Sirt6 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC443811 | View Product |
| Stable overexpression | LC543811 | View Product | |
| AAV Vector & Virus | Long-term expression | VC443811 | View Product |
| Long-term expression | VC543811 | View Product | |
| Adenovirus | Transient expression | A443811 | View Product |
| Transient expression | A543811 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG443811 | View Product |
| Gene knockout (non-viral) | PG443811 | View Product | |
| Gene knockout (AAV) | VG443811 | View Product | |
| CRISPR Activation | Gene activation | LA443811 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS443811 | View Product |
| Gene knockdown (AAV) | VS443811 | View Product | |
| ORF Vector | Template DNA | PC443811 | View Product |
| Template DNA | PC543811 | View Product |
Rat Sirt6 Gene Overview
| Gene Name | sirtuin 6 |
|---|---|
| Gene Symbol | Sirt6 |
| Synonyms | |
| NCBI ID | 299638 |
| Ensembl ID | ENSRNOG00000006393 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Enables protein lysine deacetylase activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to peptide hormone stimulus; and post-embryonic cardiac muscle cell growth involved in heart morphogenesis. Predicted to be located in chromosome, subtelomeric region and nucleoplasm. Predicted to be active in chromosome; endoplasmic reticulum; and nucleus. Biomarker of metabolic dysfunction-associated steatotic liver disease; obesity; and transient cerebral ischemia. Orthologous to human SIRT6 (sirtuin 6). [provided by Alliance of Genome Resources, Jul 2025]
Rat Sirt6 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC643811 | View Product |
| AAV Vector & Virus | Long-term expression | VC643811 | View Product |
| Adenovirus | Transient expression | A643811 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG643811 | View Product |
| Gene knockout (non-viral) | PG643811 | View Product | |
| Gene knockout (AAV) | VG643811 | View Product | |
| CRISPR Activation | Gene activation | LA643811 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS643811 | View Product |
| Gene knockdown (AAV) | VS643811 | View Product | |
| ORF Vector | Template DNA | PC643811 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |