SMAD7 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SMAD7-specific vectors and viral particles designed for reliable SMAD7 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SMAD7 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SMAD7 Gene Overview
| Gene Name | SMAD family member 7 |
|---|---|
| Gene Symbol | SMAD7 |
| Synonyms | CRCS3,MADH7,MADH8 |
| NCBI ID | 4092 |
| Ensembl ID | ENSG00000101665 |
| Uniprot ID | O15105 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Human SMAD7 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC144399 | View Product |
| AAV Vector & Virus | Long-term expression | VC144399 | View Product |
| Adenovirus | Transient expression | A144399 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG144399 | View Product |
| Gene knockout (non-viral) | PG144399 | View Product | |
| Gene knockout (AAV) | VG144399 | View Product | |
| CRISPR Activation | Gene activation | LA144399 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS144399 | View Product |
| Gene knockdown (AAV) | VS144399 | View Product | |
| ORF Vector | Template DNA | PC144399 | View Product |
Mouse Smad7 Gene Overview
| Gene Name | SMAD family member 7 |
|---|---|
| Gene Symbol | Smad7 |
| Synonyms | Madh7 |
| NCBI ID | 17131 |
| Ensembl ID | ENSMUSG00000025880 |
| Uniprot ID | O35253 |
| Gene Type | Protein coding |
Gene Summary
Enables collagen binding activity. Involved in several processes, including circulatory system development; negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within cellular response to leukemia inhibitory factor; negative regulation of BMP signaling pathway; and transforming growth factor beta receptor signaling pathway. Located in nucleus. Part of protein-containing complex. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in colorectal cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (SMAD family member 7). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Smad7 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC444399 | View Product |
| AAV Vector & Virus | Long-term expression | VC444399 | View Product |
| Adenovirus | Transient expression | A444399 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG444399 | View Product |
| Gene knockout (non-viral) | PG444399 | View Product | |
| Gene knockout (AAV) | VG444399 | View Product | |
| CRISPR Activation | Gene activation | LA444399 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS444399 | View Product |
| Gene knockdown (AAV) | VS444399 | View Product | |
| ORF Vector | Template DNA | PC444399 | View Product |
Rat Smad7 Gene Overview
| Gene Name | SMAD family member 7 |
|---|---|
| Gene Symbol | Smad7 |
| Synonyms | Madh7 |
| NCBI ID | 81516 |
| Ensembl ID | ENSRNOG00000018359 |
| Uniprot ID | O88406 |
| Gene Type | Protein coding |
Gene Summary
Enables ubiquitin protein ligase binding activity. Involved in intracellular signal transduction; negative regulation of DNA-templated transcription; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in several cellular components, including adherens junction; microtubule organizing center; and nuclear lumen. Predicted to be part of heteromeric SMAD protein complex. Predicted to be active in plasma membrane. Biomarker of nephritis and pulmonary hypertension. Human ortholog(s) of this gene implicated in colorectal cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (SMAD family member 7). [provided by Alliance of Genome Resources, Jul 2025]
Rat Smad7 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC644399 | View Product |
| AAV Vector & Virus | Long-term expression | VC644399 | View Product |
| Adenovirus | Transient expression | A644399 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG644399 | View Product |
| Gene knockout (non-viral) | PG644399 | View Product | |
| Gene knockout (AAV) | VG644399 | View Product | |
| CRISPR Activation | Gene activation | LA644399 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS644399 | View Product |
| Gene knockdown (AAV) | VS644399 | View Product | |
| ORF Vector | Template DNA | PC644399 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |