SMARCA4 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SMARCA4-specific vectors and viral particles designed for reliable SMARCA4 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SMARCA4 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SMARCA4 Gene Overview
| Gene Name | SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 |
|---|---|
| Gene Symbol | SMARCA4 |
| Synonyms | BRG1,CSS4,SNF2,SWI2,MRD16,RTPS2,BAF190,OTSC12,SNF2L4,SNF2LB,hSNF2b,BAF190A,SNF2-beta |
| NCBI ID | 6597 |
| Ensembl ID | ENSG00000127616 |
| Uniprot ID | P51532 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Human SMARCA4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Adenovirus | Transient expression | A144408 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG144408 | View Product |
| Gene knockout (non-viral) | PG144408 | View Product | |
| Gene knockout (AAV) | VG144408 | View Product | |
| CRISPR Activation | Gene activation | LA144408 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS144408 | View Product |
| Gene knockdown (AAV) | VS144408 | View Product | |
| ORF Vector | Template DNA | PC144408 | View Product |
Mouse Smarca4 Gene Overview
| Gene Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
|---|---|
| Gene Symbol | Smarca4 |
| Synonyms | Brg1,BAF190A,SW1/SNF,HP1-BP72,SNF2beta,b2b692Clo,b2b508.1Clo |
| NCBI ID | 20586 |
| Ensembl ID | ENSMUSG00000032187 |
| Uniprot ID | Q3TKT4 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including ATP hydrolysis activity; DNA polymerase binding activity; and lncRNA binding activity. Involved in nervous system development; positive regulation of Wnt signaling pathway; and positive regulation of metabolic process. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including blastocyst development; circulatory system development; and erythrocyte differentiation. Located in euchromatin; male germ cell nucleus; and perichromatin fibrils. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study breast cancer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; hepatocellular carcinoma; lung non-small cell carcinoma; and rhabdoid tumor predisposition syndrome 2. Orthologous to human SMARCA4 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Smarca4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Adenovirus | Transient expression | A444408 | View Product |
| Transient expression | A544408 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG444408 | View Product |
| Gene knockout (non-viral) | PG444408 | View Product | |
| Gene knockout (AAV) | VG444408 | View Product | |
| CRISPR Activation | Gene activation | LA444408 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS444408 | View Product |
| Gene knockdown (AAV) | VS444408 | View Product | |
| ORF Vector | Template DNA | PC444408 | View Product |
| Template DNA | PC544408 | View Product |
Rat Smarca4 Gene Overview
| Gene Name | SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 |
|---|---|
| Gene Symbol | Smarca4 |
| Synonyms | brg-1 |
| NCBI ID | 171379 |
| Ensembl ID | ENSRNOG00000009271 |
| Uniprot ID | Q8K1P7 |
| Gene Type | Protein coding |
Gene Summary
Enables chromatin binding activity. Involved in negative regulation of DNA-templated transcription; nucleosome disassembly; and spermatid development. Part of SWI/SNF complex. Used to study cocaine dependence. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; hepatocellular carcinoma; lung non-small cell carcinoma; and rhabdoid tumor predisposition syndrome 2. Orthologous to human SMARCA4 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4). [provided by Alliance of Genome Resources, Jul 2025]
Rat Smarca4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Adenovirus | Transient expression | A644408 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG644408 | View Product |
| Gene knockout (non-viral) | PG644408 | View Product | |
| Gene knockout (AAV) | VG644408 | View Product | |
| CRISPR Activation | Gene activation | LA644408 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS644408 | View Product |
| Gene knockdown (AAV) | VS644408 | View Product | |
| ORF Vector | Template DNA | PC644408 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |