SNCA Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SNCA-specific vectors and viral particles designed for reliable SNCA overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SNCA CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SNCA Gene Overview
| Gene Name | synuclein alpha |
|---|---|
| Gene Symbol | SNCA |
| Synonyms | PD1,NACP,PARK1,PARK4 |
| NCBI ID | 6622 |
| Ensembl ID | ENSG00000145335 |
| Uniprot ID | P37840 |
| Gene Type | Protein coding |
Gene Summary
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Human SNCA Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC144541 | View Product |
| AAV Vector & Virus | Long-term expression | VC144541 | View Product |
| Adenovirus | Transient expression | A144541 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG144541 | View Product |
| Gene knockout (non-viral) | PG144541 | View Product | |
| Gene knockout (AAV) | VG144541 | View Product | |
| CRISPR Activation | Gene activation | LA144541 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS144541 | View Product |
| Gene knockdown (AAV) | VS144541 | View Product | |
| ORF Vector | Template DNA | PC144541 | View Product |
Mouse Snca Gene Overview
| Gene Name | synuclein, alpha |
|---|---|
| Gene Symbol | Snca |
| Synonyms | NACP,alphaSYN,alpha-Syn |
| NCBI ID | 20617 |
| Ensembl ID | ENSMUSG00000025889 |
| Uniprot ID | O55042 |
| Gene Type | Protein coding |
Gene Summary
Enables arachidonate binding activity; histone binding activity; and identical protein binding activity. Involved in several processes, including protein-containing complex assembly; regulation of reactive oxygen species metabolic process; and synaptic vesicle endocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; modulation of chemical synaptic transmission; and regulation of amine transport. Located in several cellular components, including axon terminus; inclusion body; and neuronal cell body. Is active in synaptic vesicle membrane. Is expressed in several structures, including central nervous system; future brain; genitourinary system; sensory ganglion; and sensory organ. Used to study Parkinson's disease 1 and Parkinson's disease 4. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Snca Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC444541 | View Product |
| Stable overexpression | LC544541 | View Product | |
| AAV Vector & Virus | Long-term expression | VC444541 | View Product |
| Long-term expression | VC544541 | View Product | |
| Adenovirus | Transient expression | A444541 | View Product |
| Transient expression | A544541 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG444541 | View Product |
| Gene knockout (non-viral) | PG444541 | View Product | |
| Gene knockout (AAV) | VG444541 | View Product | |
| CRISPR Activation | Gene activation | LA444541 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS444541 | View Product |
| Gene knockdown (AAV) | VS444541 | View Product | |
| ORF Vector | Template DNA | PC444541 | View Product |
| Template DNA | PC544541 | View Product |
Rat Snca Gene Overview
| Gene Name | synuclein alpha |
|---|---|
| Gene Symbol | Snca |
| Synonyms | |
| NCBI ID | 29219 |
| Ensembl ID | ENSRNOG00000008656 |
| Uniprot ID | P37377 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including phospholipase binding activity; phospholipid binding activity; and tubulin binding activity. Involved in several processes, including behavioral response to cocaine; negative regulation of dopamine metabolic process; and response to desipramine. Located in several cellular components, including cytoplasmic vesicle; distal axon; and mitochondrion. Used to study Parkinson's disease and amphetamine abuse. Biomarker of depressive disorder and neurilemmoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha). [provided by Alliance of Genome Resources, Jul 2025]
Rat Snca Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC644541 | View Product |
| AAV Vector & Virus | Long-term expression | VC644541 | View Product |
| Adenovirus | Transient expression | A644541 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG644541 | View Product |
| Gene knockout (non-viral) | PG644541 | View Product | |
| Gene knockout (AAV) | VG644541 | View Product | |
| CRISPR Activation | Gene activation | LA644541 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS644541 | View Product |
| Gene knockdown (AAV) | VS644541 | View Product | |
| ORF Vector | Template DNA | PC644541 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |