SOD1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SOD1-specific vectors and viral particles designed for reliable SOD1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SOD1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SOD1 Gene Overview
| Gene Name | superoxide dismutase 1 |
|---|---|
| Gene Symbol | SOD1 |
| Synonyms | ALS,SOD,ALS1,IPOA,STAHP,hSod1,HEL-S-44,homodimer |
| NCBI ID | 6647 |
| Ensembl ID | ENSG00000142168 |
| Uniprot ID | P00441 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020]
Human SOD1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC245103 | View Product |
| AAV Vector & Virus | Long-term expression | VC145103 | View Product |
| Adenovirus | Transient expression | A245103 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG145103 | View Product |
| Gene knockout (non-viral) | PG145103 | View Product | |
| Gene knockout (AAV) | VG145103 | View Product | |
| CRISPR Activation | Gene activation | LA145103 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS145103 | View Product |
| Gene knockdown (AAV) | VS145103 | View Product | |
| ORF Vector | Template DNA | PC145103 | View Product |
Mouse Sod1 Gene Overview
| Gene Name | superoxide dismutase 1, soluble |
|---|---|
| Gene Symbol | Sod1 |
| Synonyms | Ipo1,SODC,Ipo-1,Sod-1,CuZnSOD,Cu/Zn-SOD,B430204E11Rik |
| NCBI ID | 20655 |
| Ensembl ID | ENSMUSG00000022982 |
| Uniprot ID | P08228 |
| Gene Type | Protein coding |
Gene Summary
Enables superoxide dismutase activity. Involved in axonal transport; negative regulation of inflammatory response; and positive regulation of phagocytosis. Acts upstream of or within several processes, including action potential initiation; determination of adult lifespan; and neurogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study amyotrophic lateral sclerosis type 1; dry eye syndrome; and low tension glaucoma. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Sod1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC445103 | View Product |
| AAV Vector & Virus | Long-term expression | VC445103 | View Product |
| Adenovirus | Transient expression | A445103 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG445103 | View Product |
| Gene knockout (non-viral) | PG445103 | View Product | |
| Gene knockout (AAV) | VG445103 | View Product | |
| CRISPR Activation | Gene activation | LA445103 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS445103 | View Product |
| Gene knockdown (AAV) | VS445103 | View Product | |
| ORF Vector | Template DNA | PC445103 | View Product |
Rat Sod1 Gene Overview
| Gene Name | superoxide dismutase 1 |
|---|---|
| Gene Symbol | Sod1 |
| Synonyms | CuZnSOD |
| NCBI ID | 24786 |
| Ensembl ID | ENSRNOG00000002115 |
| Uniprot ID | P07632 |
| Gene Type | Protein coding |
Gene Summary
Enables copper ion binding activity; protein phosphatase 2B binding activity; and superoxide dismutase activity. Involved in several processes, including hydrogen peroxide biosynthetic process; removal of superoxide radicals; and response to antipsychotic drug. Located in several cellular components, including dense core granule; neuronal cell body; and peroxisome. Part of protein-containing complex. Used to study hyperthyroidism; hypothyroidism; middle cerebral artery infarction; and sciatic neuropathy. Biomarker of several diseases, including alcohol use disorder; artery disease (multiple); congenital diaphragmatic hernia; metabolic dysfunction-associated steatohepatitis; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Sod1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC645103 | View Product |
| AAV Vector & Virus | Long-term expression | VC645103 | View Product |
| Adenovirus | Transient expression | A645103 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG645103 | View Product |
| Gene knockout (non-viral) | PG645103 | View Product | |
| Gene knockout (AAV) | VG645103 | View Product | |
| CRISPR Activation | Gene activation | LA645103 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS645103 | View Product |
| Gene knockdown (AAV) | VS645103 | View Product | |
| ORF Vector | Template DNA | PC645103 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |