SOD2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SOD2-specific vectors and viral particles designed for reliable SOD2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SOD2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SOD2 Gene Overview
| Gene Name | superoxide dismutase 2 |
|---|---|
| Gene Symbol | SOD2 |
| Synonyms | GC1,IPOB,IPO-B,MNSOD,MVCD6,GClnc1,Mn-SOD,lncRNA-GC1 |
| NCBI ID | 6648 |
| Ensembl ID | ENSG00000291237 |
| Uniprot ID | P04179 |
| Gene Type | Protein coding |
Gene Summary
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
Human SOD2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC245104 | View Product |
| Stable overexpression | LC345104 | View Product | |
| AAV Vector & Virus | Long-term expression | VC145104 | View Product |
| Long-term expression | VC245104 | View Product | |
| Adenovirus | Transient expression | A145104 | View Product |
| Transient expression | A245104 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG145104 | View Product |
| Gene knockout (non-viral) | PG145104 | View Product | |
| Gene knockout (AAV) | VG145104 | View Product | |
| CRISPR Activation | Gene activation | LA145104 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS145104 | View Product |
| Gene knockdown (AAV) | VS145104 | View Product | |
| ORF Vector | Template DNA | PC145104 | View Product |
| Template DNA | PC245104 | View Product |
Mouse Sod2 Gene Overview
| Gene Name | superoxide dismutase 2, mitochondrial |
|---|---|
| Gene Symbol | Sod2 |
| Synonyms | MnSOD,Sod-2 |
| NCBI ID | 20656 |
| Ensembl ID | ENSMUSG00000006818 |
| Uniprot ID | P09671 |
| Gene Type | Protein coding |
Gene Summary
Enables superoxide dismutase activity. Acts upstream of or within several processes, including acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure; apoptotic signaling pathway; and erythrophore differentiation. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Canavan disease; Leigh disease; amyotrophic lateral sclerosis type 1; congestive heart failure; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Sod2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC445104 | View Product |
| AAV Vector & Virus | Long-term expression | VC445104 | View Product |
| Adenovirus | Transient expression | A445104 | View Product |
| ORF Vector | Template DNA | PC445104 | View Product |
Rat Sod2 Gene Overview
| Gene Name | superoxide dismutase 2 |
|---|---|
| Gene Symbol | Sod2 |
| Synonyms | MnSOD |
| NCBI ID | 24787 |
| Ensembl ID | ENSRNOG00000086727 |
| Uniprot ID | P07895 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including manganese ion binding activity; oxygen binding activity; and superoxide dismutase activity. Involved in several processes, including cellular response to ethanol; hydrogen peroxide biosynthetic process; and negative regulation of membrane hyperpolarization. Located in mitochondrial nucleoid. Used to study esophagus adenocarcinoma; hypertension; intestinal disease; and myocardial infarction. Biomarker of several diseases, including adult respiratory distress syndrome; artery disease (multiple); bladder neck obstruction; congenital diaphragmatic hernia; and steatotic liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Sod2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC645104 | View Product |
| AAV Vector & Virus | Long-term expression | VC645104 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG645104 | View Product |
| Gene knockout (non-viral) | PG645104 | View Product | |
| Gene knockout (AAV) | VG645104 | View Product | |
| CRISPR Activation | Gene activation | LA645104 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS645104 | View Product |
| Gene knockdown (AAV) | VS645104 | View Product | |
| ORF Vector | Template DNA | PC645104 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |