SOX2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SOX2-specific vectors and viral particles designed for reliable SOX2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SOX2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SOX2 Gene Overview
| Gene Name | SRY-box transcription factor 2 |
|---|---|
| Gene Symbol | SOX2 |
| Synonyms | ANOP3,MCOPS3 |
| NCBI ID | 6657 |
| Ensembl ID | ENSG00000181449 |
| Uniprot ID | P48431 |
| Gene Type | Protein coding |
Gene Summary
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
Human SOX2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC145141 | View Product |
| AAV Vector & Virus | Long-term expression | VC145141 | View Product |
| Adenovirus | Transient expression | A245141 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG145141 | View Product |
| Gene knockout (non-viral) | PG145141 | View Product | |
| Gene knockout (AAV) | VG145141 | View Product | |
| CRISPR Activation | Gene activation | LA145141 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS145141 | View Product |
| Gene knockdown (AAV) | VS145141 | View Product | |
| ORF Vector | Template DNA | PC145141 | View Product |
Mouse Sox2 Gene Overview
| Gene Name | SRY (sex determining region Y)-box 2 |
|---|---|
| Gene Symbol | Sox2 |
| Synonyms | lcc,ysb,Sox-2 |
| NCBI ID | 20674 |
| Ensembl ID | ENSMUSG00000074637 |
| Uniprot ID | P48432 |
| Gene Type | Protein coding |
Gene Summary
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in a similar gene in human have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (Sox2ot). [provided by RefSeq, Sep 2015]
Mouse Sox2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC445141 | View Product |
| AAV Vector & Virus | Long-term expression | VC445141 | View Product |
| Adenovirus | Transient expression | A445141 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG445141 | View Product |
| Gene knockout (non-viral) | PG445141 | View Product | |
| Gene knockout (AAV) | VG445141 | View Product | |
| CRISPR Activation | Gene activation | LA445141 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS445141 | View Product |
| Gene knockdown (AAV) | VS445141 | View Product | |
| ORF Vector | Template DNA | PC445141 | View Product |
Rat Sox2 Gene Overview
| Gene Name | SRY-box transcription factor 2 |
|---|---|
| Gene Symbol | Sox2 |
| Synonyms | RGD1565646 |
| NCBI ID | 499593 |
| Ensembl ID | ENSRNOG00000090426 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; nitric-oxide synthase binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to hypoxia; regulation of myofibroblast cell apoptotic process; and response to oxygen-glucose deprivation. Located in nucleus. Used to study congestive heart failure. Biomarker of alcohol use disorder; lesion of sciatic nerve; retinal degeneration; transient cerebral ischemia; and traumatic brain injury. Human ortholog(s) of this gene implicated in breast cancer; nasal cavity cancer; oral cavity cancer; and syndromic microphthalmia 3. Orthologous to human SOX2 (SRY-box transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Sox2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC645141 | View Product |
| AAV Vector & Virus | Long-term expression | VC645141 | View Product |
| Adenovirus | Transient expression | A645141 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG645141 | View Product |
| Gene knockout (non-viral) | PG645141 | View Product | |
| Gene knockout (AAV) | VG645141 | View Product | |
| CRISPR Activation | Gene activation | LA645141 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS645141 | View Product |
| Gene knockdown (AAV) | VS645141 | View Product | |
| ORF Vector | Template DNA | PC645141 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |