SPARC Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SPARC-specific vectors and viral particles designed for reliable SPARC overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SPARC CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SPARC Gene Overview
| Gene Name | secreted protein acidic and cysteine rich |
|---|---|
| Gene Symbol | SPARC |
| Synonyms | ON,ONT,OI17,BM-40 |
| NCBI ID | 6678 |
| Ensembl ID | ENSG00000113140 |
| Uniprot ID | P09486 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]
Human SPARC Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC145208 | View Product |
| AAV Vector & Virus | Long-term expression | VC145208 | View Product |
| Adenovirus | Transient expression | A145208 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG145208 | View Product |
| Gene knockout (non-viral) | PG145208 | View Product | |
| Gene knockout (AAV) | VG145208 | View Product | |
| CRISPR Activation | Gene activation | LA145208 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS145208 | View Product |
| Gene knockdown (AAV) | VS145208 | View Product | |
| ORF Vector | Template DNA | PC145208 | View Product |
Mouse Sparc Gene Overview
| Gene Name | secreted acidic cysteine rich glycoprotein |
|---|---|
| Gene Symbol | Sparc |
| Synonyms | ON,BM-40 |
| NCBI ID | 20692 |
| Ensembl ID | ENSMUSG00000018593 |
| Uniprot ID | P07214 |
| Gene Type | Protein coding |
Gene Summary
Enables calcium ion binding activity and extracellular matrix binding activity. Acts upstream of or within several processes, including bone development; cellular response to growth factor stimulus; and pigmentation. Located in extracellular matrix and extracellular space. Is expressed in several structures, including brain; egg cylinder; genitourinary system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Sparc Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC445208 | View Product |
| AAV Vector & Virus | Long-term expression | VC445208 | View Product |
| Adenovirus | Transient expression | A445208 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG445208 | View Product |
| Gene knockout (non-viral) | PG445208 | View Product | |
| Gene knockout (AAV) | VG445208 | View Product | |
| CRISPR Activation | Gene activation | LA445208 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS445208 | View Product |
| Gene knockdown (AAV) | VS445208 | View Product | |
| ORF Vector | Template DNA | PC445208 | View Product |
Rat Sparc Gene Overview
| Gene Name | secreted protein acidic and cysteine rich |
|---|---|
| Gene Symbol | Sparc |
| Synonyms | |
| NCBI ID | 24791 |
| Ensembl ID | ENSRNOG00000012840 |
| Uniprot ID | P16975 |
| Gene Type | Protein coding |
Gene Summary
Enables calcium ion binding activity. Involved in several processes, including response to L-ascorbic acid; response to lead ion; and response to lipopolysaccharide. Located in extracellular space and vesicle. Is active in glutamatergic synapse. Biomarker of diabetic angiopathy; membranoproliferative glomerulonephritis; membranous glomerulonephritis; myocardial infarction; and stomach carcinoma. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Jul 2025]
Rat Sparc Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC645208 | View Product |
| AAV Vector & Virus | Long-term expression | VC645208 | View Product |
| Adenovirus | Transient expression | A645208 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG645208 | View Product |
| Gene knockout (non-viral) | PG645208 | View Product | |
| Gene knockout (AAV) | VG645208 | View Product | |
| CRISPR Activation | Gene activation | LA645208 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS645208 | View Product |
| Gene knockdown (AAV) | VS645208 | View Product | |
| ORF Vector | Template DNA | PC645208 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |