SPHK1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SPHK1-specific vectors and viral particles designed for reliable SPHK1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SPHK1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SPHK1 Gene Overview
| Gene Name | sphingosine kinase 1 |
|---|---|
| Gene Symbol | SPHK1 |
| Synonyms | SPHK |
| NCBI ID | 8877 |
| Ensembl ID | ENSG00000176170 |
| Uniprot ID | Q9NYA1 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
Human SPHK1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| AAV Vector & Virus | Long-term expression | VC145312 | View Product |
| Long-term expression | VC245312 | View Product | |
| Adenovirus | Transient expression | A145312 | View Product |
| Transient expression | A245312 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG145312 | View Product |
| Gene knockout (non-viral) | PG145312 | View Product | |
| Gene knockout (AAV) | VG145312 | View Product | |
| CRISPR Activation | Gene activation | LA145312 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS145312 | View Product |
| Gene knockdown (AAV) | VS145312 | View Product | |
| ORF Vector | Template DNA | PC145312 | View Product |
| Template DNA | PC245312 | View Product |
Mouse Sphk1 Gene Overview
| Gene Name | sphingosine kinase 1 |
|---|---|
| Gene Symbol | Sphk1 |
| Synonyms | Sk1,Spk1,1110006G24Rik |
| NCBI ID | 20698 |
| Ensembl ID | ENSMUSG00000061878 |
| Uniprot ID | Q8CI15 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Mouse Sphk1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC445312 | View Product |
| Stable overexpression | LC545312 | View Product | |
| AAV Vector & Virus | Long-term expression | VC445312 | View Product |
| Long-term expression | VC545312 | View Product | |
| Adenovirus | Transient expression | A445312 | View Product |
| Transient expression | A545312 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG445312 | View Product |
| Gene knockout (non-viral) | PG445312 | View Product | |
| Gene knockout (AAV) | VG445312 | View Product | |
| CRISPR Activation | Gene activation | LA445312 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS445312 | View Product |
| Gene knockdown (AAV) | VS445312 | View Product | |
| ORF Vector | Template DNA | PC445312 | View Product |
| Template DNA | PC545312 | View Product |
Rat Sphk1 Gene Overview
| Gene Name | sphingosine kinase 1 |
|---|---|
| Gene Symbol | Sphk1 |
| Synonyms | |
| NCBI ID | 170897 |
| Ensembl ID | ENSRNOG00000010626 |
| Uniprot ID | Q91V26 |
| Gene Type | Protein coding |
Gene Summary
Enables D-erythro-sphingosine kinase activity. Involved in several processes, including cellular response to phorbol 13-acetate 12-myristate; cyclooxygenase pathway; and regulation of macromolecule metabolic process. Located in axon and synaptic vesicle. Biomarker of adenocarcinoma and high grade glioma. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SPHK1 (sphingosine kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Rat Sphk1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC645312 | View Product |
| AAV Vector & Virus | Long-term expression | VC645312 | View Product |
| Adenovirus | Transient expression | A645312 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG645312 | View Product |
| Gene knockout (non-viral) | PG645312 | View Product | |
| Gene knockout (AAV) | VG645312 | View Product | |
| CRISPR Activation | Gene activation | LA645312 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS645312 | View Product |
| Gene knockdown (AAV) | VS645312 | View Product | |
| ORF Vector | Template DNA | PC645312 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |