SPP1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SPP1-specific vectors and viral particles designed for reliable SPP1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SPP1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SPP1 Gene Overview
| Gene Name | secreted phosphoprotein 1 |
|---|---|
| Gene Symbol | SPP1 |
| Synonyms | OPN,BNSP,BSPI,ETA-1 |
| NCBI ID | 6696 |
| Ensembl ID | ENSG00000118785 |
| Uniprot ID | P10451 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Human SPP1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC145369 | View Product |
| Stable overexpression | LC245369 | View Product | |
| AAV Vector & Virus | Long-term expression | VC145369 | View Product |
| Long-term expression | VC245369 | View Product | |
| Adenovirus | Transient expression | A145369 | View Product |
| Transient expression | A245369 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG145369 | View Product |
| Gene knockout (non-viral) | PG145369 | View Product | |
| Gene knockout (AAV) | VG145369 | View Product | |
| CRISPR Activation | Gene activation | LA145369 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS145369 | View Product |
| Gene knockdown (AAV) | VS145369 | View Product | |
| ORF Vector | Template DNA | PC145369 | View Product |
| Template DNA | PC245369 | View Product |
Mouse Spp1 Gene Overview
| Gene Name | secreted phosphoprotein 1 |
|---|---|
| Gene Symbol | Spp1 |
| Synonyms | OP,2AR,Bsp,Eta,Opn,Ric,BNSP,BSPI,Opnl,Apl-1,ETA-1,Spp-1 |
| NCBI ID | 20750 |
| Ensembl ID | ENSMUSG00000029304 |
| Uniprot ID | P10923 |
| Gene Type | Protein coding |
Gene Summary
Enables extracellular matrix binding activity and integrin binding activity. Involved in bone mineralization and calcium ion homeostasis. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; intracellular chloride ion homeostasis; and intracellular monoatomic cation homeostasis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system; brain; metanephros; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Spp1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC445369 | View Product |
| Stable overexpression | LC545369 | View Product | |
| AAV Vector & Virus | Long-term expression | VC445369 | View Product |
| Long-term expression | VC545369 | View Product | |
| Adenovirus | Transient expression | A445369 | View Product |
| Transient expression | A545369 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG445369 | View Product |
| Gene knockout (non-viral) | PG445369 | View Product | |
| Gene knockout (AAV) | VG445369 | View Product | |
| CRISPR Activation | Gene activation | LA445369 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS445369 | View Product |
| Gene knockdown (AAV) | VS445369 | View Product | |
| ORF Vector | Template DNA | PC445369 | View Product |
| Template DNA | PC545369 | View Product |
Rat Spp1 Gene Overview
| Gene Name | secreted phosphoprotein 1 |
|---|---|
| Gene Symbol | Spp1 |
| Synonyms | OSP |
| NCBI ID | 25353 |
| Ensembl ID | ENSRNOG00000043451 |
| Uniprot ID | P08721 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable extracellular matrix binding activity; integrin binding activity; and small molecule binding activity. Involved in several processes, including negative regulation of collateral sprouting of intact axon in response to injury; positive regulation of bone resorption; and response to macrophage colony-stimulating factor. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and vesicle. Used to study several diseases, including encephalomyelitis; glomerulonephritis; myocarditis; radiculopathy; and renovascular hypertension. Biomarker of autosomal dominant polycystic kidney disease; calcinosis; and glomerulosclerosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Spp1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC645369 | View Product |
| AAV Vector & Virus | Long-term expression | VC645369 | View Product |
| Adenovirus | Transient expression | A645369 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG645369 | View Product |
| Gene knockout (non-viral) | PG645369 | View Product | |
| Gene knockout (AAV) | VG645369 | View Product | |
| CRISPR Activation | Gene activation | LA645369 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS645369 | View Product |
| Gene knockdown (AAV) | VS645369 | View Product | |
| ORF Vector | Template DNA | PC645369 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |