SQSTM1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SQSTM1-specific vectors and viral particles designed for reliable SQSTM1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SQSTM1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SQSTM1 Gene Overview
| Gene Name | sequestosome 1 |
|---|---|
| Gene Symbol | SQSTM1 |
| Synonyms | p60,p62,A170,DMRV,OSIL,PDB3,ZIP3,p62B,EBIAP,NADGP,FTDALS3 |
| NCBI ID | 8878 |
| Ensembl ID | ENSG00000161011 |
| Uniprot ID | Q13501 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
Human SQSTM1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC245434 | View Product |
| AAV Vector & Virus | Long-term expression | VC245434 | View Product |
| Adenovirus | Transient expression | A245434 | View Product |
| ORF Vector | Template DNA | PC245434 | View Product |
Mouse Sqstm1 Gene Overview
| Gene Name | sequestosome 1 |
|---|---|
| Gene Symbol | Sqstm1 |
| Synonyms | Osi,p62,A170,STAP,OSF-6,STONE14 |
| NCBI ID | 18412 |
| Ensembl ID | ENSMUSG00000015837 |
| Uniprot ID | Q64337 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; ionotropic glutamate receptor binding activity; and molecular condensate scaffold activity. Involved in several processes, including aggrephagy; brown fat cell proliferation; and positive regulation of long-term synaptic potentiation. Acts upstream of or within energy homeostasis; negative regulation of transcription by RNA polymerase II; and temperature homeostasis. Located in several cellular components, including aggresome; sperm midpiece; and vacuole. Is active in intracellular membraneless organelle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 3; distal myopathy with rimmed vacuoles; frontotemporal dementia and/or amyotrophic lateral sclerosis 3; and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Sqstm1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC445434 | View Product |
| AAV Vector & Virus | Long-term expression | VC445434 | View Product |
| Adenovirus | Transient expression | A445434 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG445434 | View Product |
| Gene knockout (non-viral) | PG445434 | View Product | |
| Gene knockout (AAV) | VG445434 | View Product | |
| CRISPR Activation | Gene activation | LA445434 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS445434 | View Product |
| Gene knockdown (AAV) | VS445434 | View Product | |
| ORF Vector | Template DNA | PC445434 | View Product |
Rat Sqstm1 Gene Overview
| Gene Name | sequestosome 1 |
|---|---|
| Gene Symbol | Sqstm1 |
| Synonyms | Osi,ZIP,ZIP3 |
| NCBI ID | 113894 |
| Ensembl ID | ENSRNOG00000003147 |
| Uniprot ID | O08623 |
| Gene Type | Protein coding |
Gene Summary
Enables identical protein binding activity and protein kinase C binding activity. Involved in positive regulation of protein phosphorylation and response to ischemia. Located in Lewy body. Is active in glutamatergic synapse. Biomarker of acute myocardial infarction; glaucoma; and hypertension. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 3; distal myopathy with rimmed vacuoles; frontotemporal dementia and/or amyotrophic lateral sclerosis 3; and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Sqstm1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC645434 | View Product |
| Stable overexpression | LC745434 | View Product | |
| AAV Vector & Virus | Long-term expression | VC645434 | View Product |
| Long-term expression | VC745434 | View Product | |
| Adenovirus | Transient expression | A645434 | View Product |
| Transient expression | A745434 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG645434 | View Product |
| Gene knockout (non-viral) | PG645434 | View Product | |
| Gene knockout (AAV) | VG645434 | View Product | |
| CRISPR Activation | Gene activation | LA645434 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS645434 | View Product |
| Gene knockdown (AAV) | VS645434 | View Product | |
| ORF Vector | Template DNA | PC645434 | View Product |
| Template DNA | PC745434 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |