SRC Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SRC-specific vectors and viral particles designed for reliable SRC overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SRC CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SRC Gene Overview
| Gene Name | SRC proto-oncogene, non-receptor tyrosine kinase |
|---|---|
| Gene Symbol | SRC |
| Synonyms | ASV,SRC1,THC6,c-SRC,p60-Src |
| NCBI ID | 6714 |
| Ensembl ID | ENSG00000197122 |
| Uniprot ID | P12931 |
| Gene Type | Protein coding |
Gene Summary
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Human SRC Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC145438 | View Product |
| AAV Vector & Virus | Long-term expression | VC145438 | View Product |
| Adenovirus | Transient expression | A245438 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG145438 | View Product |
| Gene knockout (non-viral) | PG145438 | View Product | |
| Gene knockout (AAV) | VG145438 | View Product | |
| CRISPR Activation | Gene activation | LA145438 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS145438 | View Product |
| Gene knockdown (AAV) | VS145438 | View Product | |
| ORF Vector | Template DNA | PC145438 | View Product |
Mouse Src Gene Overview
| Gene Name | src proto-oncogene, non-receptor tyrosine kinase |
|---|---|
| Gene Symbol | Src |
| Synonyms | pp60c-src |
| NCBI ID | 20779 |
| Ensembl ID | ENSMUSG00000027646 |
| Uniprot ID | P05480 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including connexin binding activity; ephrin receptor binding activity; and scaffold protein binding activity. Involved in several processes, including bone resorption; interleukin-6-mediated signaling pathway; and positive regulation of signal transduction. Acts upstream of or within several processes, including canonical glycolysis; positive regulation of protein metabolic process; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; focal adhesion; and ruffle membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and retina. Used to study Williams-Beuren syndrome. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Src Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC445438 | View Product |
| Stable overexpression | LC545438 | View Product | |
| AAV Vector & Virus | Long-term expression | VC445438 | View Product |
| Long-term expression | VC545438 | View Product | |
| Adenovirus | Transient expression | A445438 | View Product |
| Transient expression | A545438 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG445438 | View Product |
| Gene knockout (non-viral) | PG445438 | View Product | |
| Gene knockout (AAV) | VG445438 | View Product | |
| CRISPR Activation | Gene activation | LA445438 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS445438 | View Product |
| Gene knockdown (AAV) | VS445438 | View Product | |
| ORF Vector | Template DNA | PC445438 | View Product |
| Template DNA | PC545438 | View Product |
Rat Src Gene Overview
| Gene Name | SRC proto-oncogene, non-receptor tyrosine kinase |
|---|---|
| Gene Symbol | Src |
| Synonyms | |
| NCBI ID | 83805 |
| Ensembl ID | ENSRNOG00000009495 |
| Uniprot ID | Q9WUD9 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including insulin receptor binding activity; nuclear estrogen receptor binding activity; and protein kinase C binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; cellular response to peptide hormone stimulus; and positive regulation of signal transduction. Located in several cellular components, including caveola; dendrite; and mitochondrion-derived vesicle. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Used to study Parkinsonism; brain ischemia; hypertension; status epilepticus; and type 2 diabetes mellitus. Biomarker of hepatocellular carcinoma; lesion of sciatic nerve; and pancreatic acinar cell adenocarcinoma. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2025]
Rat Src Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC645438 | View Product |
| AAV Vector & Virus | Long-term expression | VC645438 | View Product |
| Adenovirus | Transient expression | A645438 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG645438 | View Product |
| Gene knockout (non-viral) | PG645438 | View Product | |
| Gene knockout (AAV) | VG645438 | View Product | |
| CRISPR Activation | Gene activation | LA645438 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS645438 | View Product |
| Gene knockdown (AAV) | VS645438 | View Product | |
| ORF Vector | Template DNA | PC645438 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |