STAT1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use STAT1-specific vectors and viral particles designed for reliable STAT1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including STAT1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human STAT1 Gene Overview
| Gene Name | signal transducer and activator of transcription 1 |
|---|---|
| Gene Symbol | STAT1 |
| Synonyms | CANDF7,IMD31A,IMD31B,IMD31C,ISGF-3,STAT91 |
| NCBI ID | 6772 |
| Ensembl ID | ENSG00000115415 |
| Uniprot ID | P42224 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020]
Human STAT1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC145695 | View Product |
| AAV Vector & Virus | Long-term expression | VC145695 | View Product |
| Adenovirus | Transient expression | A245695 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG145695 | View Product |
| Gene knockout (non-viral) | PG145695 | View Product | |
| Gene knockout (AAV) | VG145695 | View Product | |
| CRISPR Activation | Gene activation | LA145695 | View Product |
| siRNA Tools | Gene knockdown (AAV) | VS145695 | View Product |
| ORF Vector | Template DNA | PC145695 | View Product |
Mouse Stat1 Gene Overview
| Gene Name | signal transducer and activator of transcription 1 |
|---|---|
| Gene Symbol | Stat1 |
| Synonyms | 2010005J02Rik |
| NCBI ID | 20846 |
| Ensembl ID | ENSMUSG00000026104 |
| Uniprot ID | P42225 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in cell population proliferation; cell surface receptor signaling pathway via JAK-STAT; and defense response to other organism. Acts upstream of or within with a positive effect on positive regulation of apoptotic process. Acts upstream of or within several processes, including cell surface receptor signaling pathway; negative regulation of macrophage fusion; and response to exogenous dsRNA. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skeletal musculature. Used to study breast cancer and severe acute respiratory syndrome. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast carcinoma; immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Stat1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC445695 | View Product |
| Stable overexpression | LC545695 | View Product | |
| AAV Vector & Virus | Long-term expression | VC445695 | View Product |
| Long-term expression | VC545695 | View Product | |
| Adenovirus | Transient expression | A445695 | View Product |
| Transient expression | A545695 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG445695 | View Product |
| Gene knockout (non-viral) | PG445695 | View Product | |
| Gene knockout (AAV) | VG445695 | View Product | |
| CRISPR Activation | Gene activation | LA445695 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS445695 | View Product |
| Gene knockdown (AAV) | VS445695 | View Product | |
| ORF Vector | Template DNA | PC445695 | View Product |
| Template DNA | PC545695 | View Product |
Rat Stat1 Gene Overview
| Gene Name | signal transducer and activator of transcription 1 |
|---|---|
| Gene Symbol | Stat1 |
| Synonyms | DD6G4-4 |
| NCBI ID | 25124 |
| Ensembl ID | ENSRNOG00000014079 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Enables CCR5 chemokine receptor binding activity; protein phosphatase 2A binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; positive regulation of nitric oxide biosynthetic process; and positive regulation of smooth muscle cell proliferation. Acts upstream of or within cellular response to cytokine stimulus. Located in axon and dendrite. Used to study pulmonary fibrosis. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast cancer (multiple); immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Stat1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC645695 | View Product |
| Stable overexpression | LC745695 | View Product | |
| AAV Vector & Virus | Long-term expression | VC645695 | View Product |
| Long-term expression | VC745695 | View Product | |
| Adenovirus | Transient expression | A645695 | View Product |
| Transient expression | A745695 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG645695 | View Product |
| Gene knockout (non-viral) | PG645695 | View Product | |
| Gene knockout (AAV) | VG645695 | View Product | |
| CRISPR Activation | Gene activation | LA645695 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS645695 | View Product |
| Gene knockdown (AAV) | VS645695 | View Product | |
| ORF Vector | Template DNA | PC645695 | View Product |
| Template DNA | PC745695 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |