STAT3 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use STAT3-specific vectors and viral particles designed for reliable STAT3 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including STAT3 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human STAT3 Gene Overview
| Gene Name | signal transducer and activator of transcription 3 |
|---|---|
| Gene Symbol | STAT3 |
| Synonyms | APRF,HIES,ADMIO,ADMIO1 |
| NCBI ID | 6774 |
| Ensembl ID | ENSG00000168610 |
| Uniprot ID | P40763 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]
Human STAT3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC145697 | View Product |
| Stable overexpression | LC245697 | View Product | |
| AAV Vector & Virus | Long-term expression | VC145697 | View Product |
| Long-term expression | VC245697 | View Product | |
| Adenovirus | Transient expression | A245697 | View Product |
| Transient expression | A345697 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG145697 | View Product |
| Gene knockout (non-viral) | PG145697 | View Product | |
| Gene knockout (AAV) | VG145697 | View Product | |
| CRISPR Activation | Gene activation | LA145697 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS145697 | View Product |
| Gene knockdown (AAV) | VS145697 | View Product | |
| ORF Vector | Template DNA | PC145697 | View Product |
| Template DNA | PC245697 | View Product |
Mouse Stat3 Gene Overview
| Gene Name | signal transducer and activator of transcription 3 |
|---|---|
| Gene Symbol | Stat3 |
| Synonyms | Aprf,1110034C02Rik |
| NCBI ID | 20848 |
| Ensembl ID | ENSMUSG00000004040 |
| Uniprot ID | P42227 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
Mouse Stat3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC445697 | View Product |
| Stable overexpression | LC545697 | View Product | |
| AAV Vector & Virus | Long-term expression | VC445697 | View Product |
| Long-term expression | VC545697 | View Product | |
| Adenovirus | Transient expression | A445697 | View Product |
| Transient expression | A545697 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG445697 | View Product |
| Gene knockout (non-viral) | PG445697 | View Product | |
| Gene knockout (AAV) | VG445697 | View Product | |
| CRISPR Activation | Gene activation | LA445697 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS445697 | View Product |
| Gene knockdown (AAV) | VS445697 | View Product | |
| ORF Vector | Template DNA | PC445697 | View Product |
| Template DNA | PC545697 | View Product |
Rat Stat3 Gene Overview
| Gene Name | signal transducer and activator of transcription 3 |
|---|---|
| Gene Symbol | Stat3 |
| Synonyms | |
| NCBI ID | 25125 |
| Ensembl ID | ENSRNOG00000019742 |
| Uniprot ID | P52631 |
| Gene Type | Protein coding |
Gene Summary
Enables CCR5 chemokine receptor binding activity; nuclear glucocorticoid receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of hydrogen peroxide biosynthetic process; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of nucleobase-containing compound metabolic process. Acts upstream of or within cellular response to cytokine stimulus. Located in cytosol; mitochondrial inner membrane; and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; metabolic dysfunction-associated steatotic liver disease; obesity; and transient cerebral ischemia. Biomarker of atherosclerosis; colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3). [provided by Alliance of Genome Resources, Jul 2025]
Rat Stat3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC645697 | View Product |
| AAV Vector & Virus | Long-term expression | VC645697 | View Product |
| Adenovirus | Transient expression | A645697 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG645697 | View Product |
| Gene knockout (non-viral) | PG645697 | View Product | |
| Gene knockout (AAV) | VG645697 | View Product | |
| CRISPR Activation | Gene activation | LA645697 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS645697 | View Product |
| Gene knockdown (AAV) | VS645697 | View Product | |
| ORF Vector | Template DNA | PC645697 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |