STAT6 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use STAT6-specific vectors and viral particles designed for reliable STAT6 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including STAT6 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human STAT6 Gene Overview
| Gene Name | signal transducer and activator of transcription 6 |
|---|---|
| Gene Symbol | STAT6 |
| Synonyms | HIES6,STAT6B,STAT6C,D12S1644,IL-4-STAT |
| NCBI ID | 6778 |
| Ensembl ID | ENSG00000166888 |
| Uniprot ID | P42226 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Human STAT6 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC145701 | View Product |
| AAV Vector & Virus | Long-term expression | VC145701 | View Product |
| Adenovirus | Transient expression | A145701 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG145701 | View Product |
| Gene knockout (non-viral) | PG145701 | View Product | |
| Gene knockout (AAV) | VG145701 | View Product | |
| CRISPR Activation | Gene activation | LA145701 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS145701 | View Product |
| Gene knockdown (AAV) | VS145701 | View Product | |
| ORF Vector | Template DNA | PC145701 | View Product |
Mouse Stat6 Gene Overview
| Gene Name | signal transducer and activator of transcription 6 |
|---|---|
| Gene Symbol | Stat6 |
| Synonyms | |
| NCBI ID | 20852 |
| Ensembl ID | ENSMUSG00000002147 |
| Uniprot ID | P52633 |
| Gene Type | Protein coding |
Gene Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in gene expression; interleukin-4-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including T-helper 1 cell lineage commitment; mammary gland development; and regulation of nucleobase-containing compound metabolic process. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including 2-cell stage embryo; gut; lower urinary tract; male reproductive system; and olfactory epithelium. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lipoid nephrosis; prostate carcinoma; rectum adenocarcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Stat6 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC445701 | View Product |
| AAV Vector & Virus | Long-term expression | VC445701 | View Product |
| Adenovirus | Transient expression | A445701 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG445701 | View Product |
| Gene knockout (non-viral) | PG445701 | View Product | |
| Gene knockout (AAV) | VG445701 | View Product | |
| CRISPR Activation | Gene activation | LA445701 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS445701 | View Product |
| Gene knockdown (AAV) | VS445701 | View Product | |
| ORF Vector | Template DNA | PC445701 | View Product |
Rat Stat6 Gene Overview
| Gene Name | signal transducer and activator of transcription 6 |
|---|---|
| Gene Symbol | Stat6 |
| Synonyms | |
| NCBI ID | 362896 |
| Ensembl ID | ENSRNOG00000025023 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Used to study asthma and renal fibrosis. Biomarker of asthma and myocarditis. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lipoid nephrosis; prostate carcinoma; rectum adenocarcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6). [provided by Alliance of Genome Resources, Jul 2025]
Rat Stat6 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC645701 | View Product |
| AAV Vector & Virus | Long-term expression | VC645701 | View Product |
| Adenovirus | Transient expression | A645701 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG645701 | View Product |
| Gene knockout (non-viral) | PG645701 | View Product | |
| Gene knockout (AAV) | VG645701 | View Product | |
| CRISPR Activation | Gene activation | LA645701 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS645701 | View Product |
| Gene knockdown (AAV) | VS645701 | View Product | |
| ORF Vector | Template DNA | PC645701 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |