STK11 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use STK11-specific vectors and viral particles designed for reliable STK11 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including STK11 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human STK11 Gene Overview
| Gene Name | serine/threonine kinase 11 |
|---|---|
| Gene Symbol | STK11 |
| Synonyms | PJS,LKB1,hLKB1 |
| NCBI ID | 6794 |
| Ensembl ID | ENSG00000118046 |
| Uniprot ID | Q15831 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers. [provided by RefSeq, May 2022]
Human STK11 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC145728 | View Product |
| AAV Vector & Virus | Long-term expression | VC145728 | View Product |
| Adenovirus | Transient expression | A245728 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG145728 | View Product |
| Gene knockout (non-viral) | PG145728 | View Product | |
| Gene knockout (AAV) | VG145728 | View Product | |
| CRISPR Activation | Gene activation | LA145728 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS145728 | View Product |
| Gene knockdown (AAV) | VS145728 | View Product | |
| ORF Vector | Template DNA | PC145728 | View Product |
Mouse Stk11 Gene Overview
| Gene Name | serine/threonine kinase 11 |
|---|---|
| Gene Symbol | Stk11 |
| Synonyms | Lkb1,Par-4 |
| NCBI ID | 20869 |
| Ensembl ID | ENSMUSG00000003068 |
| Uniprot ID | Q9WTK7 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]
Mouse Stk11 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC445728 | View Product |
| AAV Vector & Virus | Long-term expression | VC445728 | View Product |
| Adenovirus | Transient expression | A445728 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG445728 | View Product |
| Gene knockout (non-viral) | PG445728 | View Product | |
| Gene knockout (AAV) | VG445728 | View Product | |
| CRISPR Activation | Gene activation | LA445728 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS445728 | View Product |
| Gene knockdown (AAV) | VS445728 | View Product | |
| ORF Vector | Template DNA | PC445728 | View Product |
Rat Stk11 Gene Overview
| Gene Name | serine/threonine kinase 11 |
|---|---|
| Gene Symbol | Stk11 |
| Synonyms | Lkb1 |
| NCBI ID | 314621 |
| Ensembl ID | ENSRNOG00000014287 |
| Uniprot ID | D4AE59 |
| Gene Type | Protein coding |
Gene Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of gluconeogenesis; response to glucagon; and response to thyroid hormone. Located in Z disc. Part of protein-containing complex. Biomarker of hyperthyroidism and obesity. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; familial melanoma; female reproductive organ cancer (multiple); and pancreatic cancer. Orthologous to human STK11 (serine/threonine kinase 11). [provided by Alliance of Genome Resources, Jul 2025]
Rat Stk11 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC645728 | View Product |
| AAV Vector & Virus | Long-term expression | VC645728 | View Product |
| Adenovirus | Transient expression | A645728 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG645728 | View Product |
| Gene knockout (non-viral) | PG645728 | View Product | |
| Gene knockout (AAV) | VG645728 | View Product | |
| CRISPR Activation | Gene activation | LA645728 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS645728 | View Product |
| Gene knockdown (AAV) | VS645728 | View Product | |
| ORF Vector | Template DNA | PC645728 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |