SUFU Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use SUFU-specific vectors and viral particles designed for reliable SUFU overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including SUFU CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human SUFU Gene Overview
| Gene Name | SUFU negative regulator of hedgehog signaling |
|---|---|
| Gene Symbol | SUFU |
| Synonyms | BCNS2,SUFUH,JBTS32,SUFUXL,PRO1280 |
| NCBI ID | 51684 |
| Ensembl ID | ENSG00000107882 |
| Uniprot ID | Q9UMX1 |
| Gene Type | Protein coding |
Gene Summary
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Human SUFU Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC145829 | View Product |
| AAV Vector & Virus | Long-term expression | VC145829 | View Product |
| Adenovirus | Transient expression | A145829 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG145829 | View Product |
| Gene knockout (non-viral) | PG145829 | View Product | |
| Gene knockout (AAV) | VG145829 | View Product | |
| CRISPR Activation | Gene activation | LA145829 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS145829 | View Product |
| Gene knockdown (AAV) | VS145829 | View Product | |
| ORF Vector | Template DNA | PC145829 | View Product |
Mouse Sufu Gene Overview
| Gene Name | SUFU negative regulator of hedgehog signaling |
|---|---|
| Gene Symbol | Sufu |
| Synonyms | Su(fu) |
| NCBI ID | 24069 |
| Ensembl ID | ENSMUSG00000025231 |
| Uniprot ID | Q9Z0P7 |
| Gene Type | Protein coding |
Gene Summary
Enables beta-catenin binding activity and protein sequestering activity. Involved in negative regulation of smoothened signaling pathway. Acts upstream of or within several processes, including circulatory system development; negative regulation of macromolecule metabolic process; and regionalization. Located in cilium; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; sensory organ; and testis. Used to study nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome 2. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Sufu Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC445829 | View Product |
| Stable overexpression | LC545829 | View Product | |
| AAV Vector & Virus | Long-term expression | VC445829 | View Product |
| Long-term expression | VC545829 | View Product | |
| Adenovirus | Transient expression | A445829 | View Product |
| Transient expression | A545829 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG445829 | View Product |
| Gene knockout (non-viral) | PG445829 | View Product | |
| Gene knockout (AAV) | VG445829 | View Product | |
| CRISPR Activation | Gene activation | LA445829 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS445829 | View Product |
| Gene knockdown (AAV) | VS445829 | View Product | |
| ORF Vector | Template DNA | PC445829 | View Product |
| Template DNA | PC545829 | View Product |
Rat Sufu Gene Overview
| Gene Name | SUFU negative regulator of hedgehog signaling |
|---|---|
| Gene Symbol | Sufu |
| Synonyms | |
| NCBI ID | 361769 |
| Ensembl ID | ENSRNOG00000019807 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable beta-catenin binding activity and protein kinase binding activity. Involved in positive regulation of cellular response to drug and spermatid development. Predicted to be located in cilium and nucleoplasm. Predicted to be part of GLI-SUFU complex. Predicted to be active in cytoplasm and nucleus. Used to study medulloblastoma. Biomarker of brain glioblastoma multiforme and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome 2. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling). [provided by Alliance of Genome Resources, Apr 2025]
Rat Sufu Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC645829 | View Product |
| AAV Vector & Virus | Long-term expression | VC645829 | View Product |
| Adenovirus | Transient expression | A645829 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG645829 | View Product |
| Gene knockout (non-viral) | PG645829 | View Product | |
| Gene knockout (AAV) | VG645829 | View Product | |
| CRISPR Activation | Gene activation | LA645829 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS645829 | View Product |
| Gene knockdown (AAV) | VS645829 | View Product | |
| ORF Vector | Template DNA | PC645829 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |