TBK1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TBK1-specific vectors and viral particles designed for reliable TBK1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TBK1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TBK1 Gene Overview
| Gene Name | TANK binding kinase 1 |
|---|---|
| Gene Symbol | TBK1 |
| Synonyms | NAK,T2K,AIARV,IIAE8,FTDALS4 |
| NCBI ID | 29110 |
| Ensembl ID | ENSG00000183735 |
| Uniprot ID | Q9UHD2 |
| Gene Type | Protein coding |
Gene Summary
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021]
Human TBK1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC146283 | View Product |
| AAV Vector & Virus | Long-term expression | VC146283 | View Product |
| Adenovirus | Transient expression | A146283 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG146283 | View Product |
| Gene knockout (non-viral) | PG146283 | View Product | |
| Gene knockout (AAV) | VG146283 | View Product | |
| CRISPR Activation | Gene activation | LA146283 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS146283 | View Product |
| Gene knockdown (AAV) | VS146283 | View Product | |
| ORF Vector | Template DNA | PC146283 | View Product |
Mouse Tbk1 Gene Overview
| Gene Name | TANK-binding kinase 1 |
|---|---|
| Gene Symbol | Tbk1 |
| Synonyms | 1200008B05Rik |
| NCBI ID | 56480 |
| Ensembl ID | ENSMUSG00000020115 |
| Uniprot ID | Q9WUN2 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including identical protein binding activity; protein phosphatase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including peptidyl-serine phosphorylation; positive regulation of signal transduction; and positive regulation of xenophagy. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis 4. Orthologous to human TBK1 (TANK binding kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Tbk1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC446283 | View Product |
| AAV Vector & Virus | Long-term expression | VC446283 | View Product |
| Adenovirus | Transient expression | A446283 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG446283 | View Product |
| Gene knockout (non-viral) | PG446283 | View Product | |
| Gene knockout (AAV) | VG446283 | View Product | |
| CRISPR Activation | Gene activation | LA446283 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS446283 | View Product |
| Gene knockdown (AAV) | VS446283 | View Product | |
| ORF Vector | Template DNA | PC446283 | View Product |
Rat Tbk1 Gene Overview
| Gene Name | TANK-binding kinase 1 |
|---|---|
| Gene Symbol | Tbk1 |
| Synonyms | |
| NCBI ID | 299827 |
| Ensembl ID | ENSRNOG00000005528 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including identical protein binding activity; protein kinase activity; and protein phosphatase binding activity. Predicted to be involved in several processes, including positive regulation of defense response; protein phosphorylation; and regulation of signal transduction. Predicted to act upstream of or within defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis 4. Orthologous to human TBK1 (TANK binding kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Rat Tbk1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC646283 | View Product |
| AAV Vector & Virus | Long-term expression | VC646283 | View Product |
| Adenovirus | Transient expression | A646283 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG646283 | View Product |
| Gene knockout (non-viral) | PG646283 | View Product | |
| Gene knockout (AAV) | VG646283 | View Product | |
| CRISPR Activation | Gene activation | LA646283 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS646283 | View Product |
| Gene knockdown (AAV) | VS646283 | View Product | |
| ORF Vector | Template DNA | PC646283 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |