TBX21 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TBX21-specific vectors and viral particles designed for reliable TBX21 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TBX21 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TBX21 Gene Overview
| Gene Name | T-box transcription factor 21 |
|---|---|
| Gene Symbol | TBX21 |
| Synonyms | TBET,IMD88,T-PET,T-bet,TBLYM |
| NCBI ID | 30009 |
| Ensembl ID | ENSG00000073861 |
| Uniprot ID | Q9UL17 |
| Gene Type | Protein coding |
Gene Summary
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
Human TBX21 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC146305 | View Product |
| AAV Vector & Virus | Long-term expression | VC146305 | View Product |
| Adenovirus | Transient expression | A146305 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG146305 | View Product |
| Gene knockout (non-viral) | PG146305 | View Product | |
| Gene knockout (AAV) | VG146305 | View Product | |
| CRISPR Activation | Gene activation | LA146305 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS146305 | View Product |
| Gene knockdown (AAV) | VS146305 | View Product | |
| ORF Vector | Template DNA | PC146305 | View Product |
Mouse Tbx21 Gene Overview
| Gene Name | T-box 21 |
|---|---|
| Gene Symbol | Tbx21 |
| Synonyms | TBT1,Tbet,Tblym |
| NCBI ID | 57765 |
| Ensembl ID | ENSMUSG00000001444 |
| Uniprot ID | Q9JKD8 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including T-helper 1 cell lineage commitment; negative regulation of T-helper 17 cell lineage commitment; and regulation of gene expression. Acts upstream of or within T cell differentiation and positive regulation of isotype switching to IgG isotypes. Located in neuronal cell body and nucleus. Is expressed in several structures, including central nervous system; colon; genitourinary system; sensory organ; and thymus. Used to study asthma. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance and immunodeficiency 88. Orthologous to human TBX21 (T-box transcription factor 21). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Tbx21 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC446305 | View Product |
| AAV Vector & Virus | Long-term expression | VC446305 | View Product |
| Adenovirus | Transient expression | A446305 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG446305 | View Product |
| Gene knockout (non-viral) | PG446305 | View Product | |
| Gene knockout (AAV) | VG446305 | View Product | |
| CRISPR Activation | Gene activation | LA446305 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS446305 | View Product |
| Gene knockdown (AAV) | VS446305 | View Product | |
| ORF Vector | Template DNA | PC446305 | View Product |
Rat Tbx21 Gene Overview
| Gene Name | T-box transcription factor 21 |
|---|---|
| Gene Symbol | Tbx21 |
| Synonyms | |
| NCBI ID | 303496 |
| Ensembl ID | ENSRNOG00000009427 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including T-helper 1 cell lineage commitment; negative regulation of T-helper 17 cell lineage commitment; and regulation of gene expression. Predicted to act upstream of or within T cell differentiation and positive regulation of isotype switching to IgG isotypes. Predicted to be located in neuronal cell body. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance and immunodeficiency 88. Orthologous to human TBX21 (T-box transcription factor 21). [provided by Alliance of Genome Resources, Jul 2025]
Rat Tbx21 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC646305 | View Product |
| AAV Vector & Virus | Long-term expression | VC646305 | View Product |
| Adenovirus | Transient expression | A646305 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG646305 | View Product |
| Gene knockout (non-viral) | PG646305 | View Product | |
| Gene knockout (AAV) | VG646305 | View Product | |
| CRISPR Activation | Gene activation | LA646305 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS646305 | View Product |
| Gene knockdown (AAV) | VS646305 | View Product | |
| ORF Vector | Template DNA | PC646305 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |