TERT Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TERT-specific vectors and viral particles designed for reliable TERT overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TERT CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TERT Gene Overview
| Gene Name | telomerase reverse transcriptase |
|---|---|
| Gene Symbol | TERT |
| Synonyms | TP2,TRT,CMM9,EST2,TCS1,hTRT,DKCA2,DKCB4,hEST2,PFBMFT1 |
| NCBI ID | 7015 |
| Ensembl ID | ENSG00000164362 |
| Uniprot ID | O14746 |
| Gene Type | Protein coding |
Gene Summary
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]
Human TERT Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Adenovirus | Transient expression | A146506 | View Product |
Mouse Tert Gene Overview
| Gene Name | telomerase reverse transcriptase |
|---|---|
| Gene Symbol | Tert |
| Synonyms | TR,TP2,TRT,EST2,TCS1 |
| NCBI ID | 21752 |
| Ensembl ID | ENSMUSG00000021611 |
| Uniprot ID | O70372 |
| Gene Type | Protein coding |
Gene Summary
Enables telomerase RNA binding activity; telomerase activity; and transcription coactivator binding activity. Involved in positive regulation of Wnt signaling pathway; positive regulation of hair cycle; and positive regulation of stem cell proliferation. Acts upstream of or within positive regulation of D-glucose import. Located in mitochondrion and plasma membrane. Part of telomerase catalytic core complex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; sensory organ; and skin. Used to study prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; carcinoma (multiple); gastrointestinal stromal tumor; leukemia (multiple); and melanoma (multiple). Orthologous to human TERT (telomerase reverse transcriptase). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Tert Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Adenovirus | Transient expression | A446506 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG446506 | View Product |
| Gene knockout (non-viral) | PG446506 | View Product | |
| Gene knockout (AAV) | VG446506 | View Product | |
| CRISPR Activation | Gene activation | LA446506 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS446506 | View Product |
| Gene knockdown (AAV) | VS446506 | View Product | |
| ORF Vector | Template DNA | PC446506 | View Product |
Rat Tert Gene Overview
| Gene Name | telomerase reverse transcriptase |
|---|---|
| Gene Symbol | Tert |
| Synonyms | |
| NCBI ID | 301965 |
| Ensembl ID | ENSRNOG00000025327 |
| Uniprot ID | Q673L6 |
| Gene Type | Protein coding |
Gene Summary
Enables telomerase activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of transdifferentiation; and positive regulation of vascular associated smooth muscle cell migration. Located in mitochondrion. Used to study chronic kidney disease and transient cerebral ischemia. Biomarker of hepatocellular carcinoma; pulmonary hypertension; and silicosis. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; carcinoma (multiple); gastrointestinal stromal tumor; leukemia (multiple); and melanoma (multiple). Orthologous to human TERT (telomerase reverse transcriptase). [provided by Alliance of Genome Resources, Jul 2025]
Rat Tert Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Adenovirus | Transient expression | A646506 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG646506 | View Product |
| Gene knockout (non-viral) | PG646506 | View Product | |
| Gene knockout (AAV) | VG646506 | View Product | |
| CRISPR Activation | Gene activation | LA646506 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS646506 | View Product |
| Gene knockdown (AAV) | VS646506 | View Product | |
| ORF Vector | Template DNA | PC646506 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |