TGFB1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TGFB1-specific vectors and viral particles designed for reliable TGFB1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TGFB1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TGFB1 Gene Overview
| Gene Name | transforming growth factor beta 1 |
|---|---|
| Gene Symbol | TGFB1 |
| Synonyms | CED,LAP,DPD1,TGFB,CAEND1,IBDIMDE,TGFbeta,TGF-beta1 |
| NCBI ID | 7040 |
| Ensembl ID | ENSG00000105329 |
| Uniprot ID | P01137 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
Human TGFB1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC146590 | View Product |
| AAV Vector & Virus | Long-term expression | VC146590 | View Product |
| Adenovirus | Transient expression | A146590 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG146590 | View Product |
| Gene knockout (non-viral) | PG146590 | View Product | |
| Gene knockout (AAV) | VG146590 | View Product | |
| CRISPR Activation | Gene activation | LA146590 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS146590 | View Product |
| Gene knockdown (AAV) | VS146590 | View Product | |
| ORF Vector | Template DNA | PC146590 | View Product |
Mouse Tgfb1 Gene Overview
| Gene Name | transforming growth factor, beta 1 |
|---|---|
| Gene Symbol | Tgfb1 |
| Synonyms | Tgfb,Tgfb-1,TGFbeta1,TGF-beta1 |
| NCBI ID | 21803 |
| Ensembl ID | ENSMUSG00000002603 |
| Uniprot ID | P04202 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. Mice lacking a functional copy of this gene develop severe multifocal inflammatory disease, yolk sac defects and colon cancer. [provided by RefSeq, Aug 2016]
Mouse Tgfb1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC446590 | View Product |
| AAV Vector & Virus | Long-term expression | VC446590 | View Product |
| Adenovirus | Transient expression | A446590 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG446590 | View Product |
| Gene knockout (non-viral) | PG446590 | View Product | |
| Gene knockout (AAV) | VG446590 | View Product | |
| CRISPR Activation | Gene activation | LA446590 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS446590 | View Product |
| Gene knockdown (AAV) | VS446590 | View Product | |
| ORF Vector | Template DNA | PC446590 | View Product |
Rat Tgfb1 Gene Overview
| Gene Name | transforming growth factor, beta 1 |
|---|---|
| Gene Symbol | Tgfb1 |
| Synonyms | Tgfb |
| NCBI ID | 59086 |
| Ensembl ID | ENSRNOG00000020652 |
| Uniprot ID | P17246 |
| Gene Type | Protein coding |
Gene Summary
Enables identical protein binding activity. Involved in several processes, including cellular response to acetaldehyde; negative regulation of transport; and regulation of epithelial cell proliferation. Acts upstream of or within positive regulation of smooth muscle cell differentiation. Located in several cellular components, including cell surface; neuronal cell body; and secretory granule. Used to study chronic obstructive pulmonary disease; familial hyperlipidemia; hypertension; proteinuria; and pulmonary fibrosis. Biomarker of several diseases, including allergic rhinitis; artery disease (multiple); cerebrovascular disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; artery disease (multiple); bone disease (multiple); carcinoma (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Tgfb1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC646590 | View Product |
| AAV Vector & Virus | Long-term expression | VC646590 | View Product |
| Adenovirus | Transient expression | A646590 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG646590 | View Product |
| Gene knockout (non-viral) | PG646590 | View Product | |
| Gene knockout (AAV) | VG646590 | View Product | |
| CRISPR Activation | Gene activation | LA646590 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS646590 | View Product |
| Gene knockdown (AAV) | VS646590 | View Product | |
| ORF Vector | Template DNA | PC646590 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |