TGFBR2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TGFBR2-specific vectors and viral particles designed for reliable TGFBR2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TGFBR2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TGFBR2 Gene Overview
| Gene Name | transforming growth factor beta receptor 2 |
|---|---|
| Gene Symbol | TGFBR2 |
| Synonyms | AAT3,FAA3,LDS2,MFS2,RIIC,LDS1B,LDS2B,TAAD2,TBRII,TBR-ii,TGFR-2,tbetaR-II,TGFbeta-RII |
| NCBI ID | 7048 |
| Ensembl ID | ENSG00000163513 |
| Uniprot ID | P37173 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]
Human TGFBR2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC146596 | View Product |
| AAV Vector & Virus | Long-term expression | VC146596 | View Product |
| Adenovirus | Transient expression | A146596 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG146596 | View Product |
| Gene knockout (non-viral) | PG146596 | View Product | |
| Gene knockout (AAV) | VG146596 | View Product | |
| CRISPR Activation | Gene activation | LA146596 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS146596 | View Product |
| Gene knockdown (AAV) | VS146596 | View Product | |
| ORF Vector | Template DNA | PC146596 | View Product |
Mouse Tgfbr2 Gene Overview
| Gene Name | transforming growth factor, beta receptor II |
|---|---|
| Gene Symbol | Tgfbr2 |
| Synonyms | DNIIR,RIIDN,TBR-II,TbetaRII,TbetaR-II,1110020H15Rik |
| NCBI ID | 21813 |
| Ensembl ID | ENSMUSG00000032440 |
| Uniprot ID | Q62312 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including SMAD binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity. Involved in several processes, including circulatory system development; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; and skeletal system development. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of tolerance induction; and respiratory system development. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; embryo mesenchyme; genitourinary system; and nervous system. Used to study DiGeorge syndrome; Loeys-Dietz syndrome; cleft soft palate; lung cancer; and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Tgfbr2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC446596 | View Product |
| Stable overexpression | LC546596 | View Product | |
| AAV Vector & Virus | Long-term expression | VC446596 | View Product |
| Long-term expression | VC546596 | View Product | |
| Adenovirus | Transient expression | A446596 | View Product |
| Transient expression | A546596 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG446596 | View Product |
| Gene knockout (non-viral) | PG446596 | View Product | |
| Gene knockout (AAV) | VG446596 | View Product | |
| CRISPR Activation | Gene activation | LA446596 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS446596 | View Product |
| Gene knockdown (AAV) | VS446596 | View Product | |
| ORF Vector | Template DNA | PC446596 | View Product |
| Template DNA | PC546596 | View Product |
Rat Tgfbr2 Gene Overview
| Gene Name | transforming growth factor, beta receptor 2 |
|---|---|
| Gene Symbol | Tgfbr2 |
| Synonyms | Tgfbr2T,TGF-beta 2 |
| NCBI ID | 81810 |
| Ensembl ID | ENSRNOG00000013265 |
| Uniprot ID | P38438 |
| Gene Type | Protein coding |
Gene Summary
Enables mitogen-activated protein kinase kinase kinase binding activity and transforming growth factor beta receptor activity, type II. Involved in several processes, including cellular response to acetaldehyde; negative regulation of cardiac muscle cell proliferation; and transforming growth factor beta receptor signaling pathway. Located in caveola and cell surface. Used to study membranoproliferative glomerulonephritis. Biomarker of artery disease (multiple); hepatobiliary system cancer (multiple); kidney disease; pulmonary fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Tgfbr2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC646596 | View Product |
| AAV Vector & Virus | Long-term expression | VC646596 | View Product |
| Adenovirus | Transient expression | A646596 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG646596 | View Product |
| Gene knockout (non-viral) | PG646596 | View Product | |
| Gene knockout (AAV) | VG646596 | View Product | |
| CRISPR Activation | Gene activation | LA646596 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS646596 | View Product |
| Gene knockdown (AAV) | VS646596 | View Product | |
| ORF Vector | Template DNA | PC646596 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |