TICAM1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TICAM1-specific vectors and viral particles designed for reliable TICAM1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TICAM1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TICAM1 Gene Overview
| Gene Name | TIR domain containing adaptor molecule 1 |
|---|---|
| Gene Symbol | TICAM1 |
| Synonyms | TRIF,IIAE6,MyD88-3,PRVTIRB,TICAM-1 |
| NCBI ID | 148022 |
| Ensembl ID | ENSG00000127666 |
| Uniprot ID | Q8IUC6 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]
Human TICAM1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC146690 | View Product |
| AAV Vector & Virus | Long-term expression | VC146690 | View Product |
| Adenovirus | Transient expression | A146690 | View Product |
| ORF Vector | Template DNA | PC146690 | View Product |
Mouse Ticam1 Gene Overview
| Gene Name | TIR domain containing adaptor molecule 1 |
|---|---|
| Gene Symbol | Ticam1 |
| Synonyms | TRIF,TICAM-1 |
| NCBI ID | 106759 |
| Ensembl ID | ENSMUSG00000047123 |
| Uniprot ID | Q80UF7 |
| Gene Type | Protein coding |
Gene Summary
Enables signaling adaptor activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of cytokine production. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of lymphocyte activation; and positive regulation of metabolic process. Located in cytosol and mitochondrion. Is expressed in brain and genitourinary system. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TICAM1 (TIR domain containing adaptor molecule 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Ticam1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC446690 | View Product |
| AAV Vector & Virus | Long-term expression | VC446690 | View Product |
| Adenovirus | Transient expression | A446690 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG446690 | View Product |
| Gene knockout (non-viral) | PG446690 | View Product | |
| Gene knockout (AAV) | VG446690 | View Product | |
| CRISPR Activation | Gene activation | LA446690 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS446690 | View Product |
| Gene knockdown (AAV) | VS446690 | View Product | |
| ORF Vector | Template DNA | PC446690 | View Product |
Rat Ticam1 Gene Overview
| Gene Name | TIR domain containing adaptor molecule 1 |
|---|---|
| Gene Symbol | Ticam1 |
| Synonyms | |
| NCBI ID | 363328 |
| Ensembl ID | ENSRNOG00000080915 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable protein kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; pattern recognition receptor signaling pathway; and positive regulation of cytokine production. Predicted to act upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of lymphocyte activation; and positive regulation of metabolic process. Predicted to be located in cytosol and mitochondrion. Predicted to be part of ripoptosome. Predicted to be active in early endosome and endosome membrane. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TICAM1 (TIR domain containing adaptor molecule 1). [provided by Alliance of Genome Resources, Apr 2025]
Rat Ticam1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |