TLR4 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TLR4-specific vectors and viral particles designed for reliable TLR4 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TLR4 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TLR4 Gene Overview
| Gene Name | toll like receptor 4 |
|---|---|
| Gene Symbol | TLR4 |
| Synonyms | TOLL,CD284,TLR-4,ARMD10 |
| NCBI ID | 7099 |
| Ensembl ID | ENSG00000136869 |
| Uniprot ID | O00206 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
Human TLR4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC146778 | View Product |
| AAV Vector & Virus | Long-term expression | VC146778 | View Product |
| Adenovirus | Transient expression | A146778 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG146778 | View Product |
| Gene knockout (non-viral) | PG146778 | View Product | |
| Gene knockout (AAV) | VG146778 | View Product | |
| CRISPR Activation | Gene activation | LA146778 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS146778 | View Product |
| Gene knockdown (AAV) | VS146778 | View Product | |
| ORF Vector | Template DNA | PC146778 | View Product |
Mouse Tlr4 Gene Overview
| Gene Name | toll-like receptor 4 |
|---|---|
| Gene Symbol | Tlr4 |
| Synonyms | Lps,Ly87,Ran/M1,Rasl2-8 |
| NCBI ID | 21898 |
| Ensembl ID | ENSMUSG00000039005 |
| Uniprot ID | Q9QUK6 |
| Gene Type | Protein coding |
Gene Summary
This gene belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls. [provided by RefSeq, Sep 2015]
Mouse Tlr4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC446778 | View Product |
| AAV Vector & Virus | Long-term expression | VC446778 | View Product |
| Adenovirus | Transient expression | A546778 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG446778 | View Product |
| Gene knockout (non-viral) | PG446778 | View Product | |
| Gene knockout (AAV) | VG446778 | View Product | |
| CRISPR Activation | Gene activation | LA446778 | View Product |
| siRNA Tools | Gene knockdown (AAV) | VS446778 | View Product |
| ORF Vector | Template DNA | PC446778 | View Product |
Rat Tlr4 Gene Overview
| Gene Name | toll-like receptor 4 |
|---|---|
| Gene Symbol | Tlr4 |
| Synonyms | |
| NCBI ID | 29260 |
| Ensembl ID | ENSRNOG00000010522 |
| Uniprot ID | Q9QX05 |
| Gene Type | Protein coding |
Gene Summary
Enables lipopolysaccharide binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including cellular response to mechanical stimulus; detection of stimulus involved in sensory perception of pain; and regulation of macromolecule metabolic process. Located in cell surface. Used to study several diseases, including carotid stenosis; ileitis; neuropathy (multiple); obesity; and renal fibrosis. Biomarker of several diseases, including alcohol use disorder; familial combined hyperlipidemia; kidney failure (multiple); liver disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4). [provided by Alliance of Genome Resources, Jul 2025]
Rat Tlr4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC646778 | View Product |
| AAV Vector & Virus | Long-term expression | VC646778 | View Product |
| Adenovirus | Transient expression | A646778 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG646778 | View Product |
| Gene knockout (non-viral) | PG646778 | View Product | |
| Gene knockout (AAV) | VG646778 | View Product | |
| CRISPR Activation | Gene activation | LA646778 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS646778 | View Product |
| Gene knockdown (AAV) | VS646778 | View Product | |
| ORF Vector | Template DNA | PC646778 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |