TMC2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TMC2-specific vectors and viral particles designed for reliable TMC2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TMC2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TMC2 Gene Overview
| Gene Name | transmembrane channel like 2 |
|---|---|
| Gene Symbol | TMC2 |
| Synonyms | C20orf145 |
| NCBI ID | 117532 |
| Ensembl ID | ENSG00000149488 |
| Uniprot ID | Q8TDI7 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a transmembrane protein that is necesssary for mechanotransduction in cochlear hair cells of the inner ear. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Aug 2015]
Human TMC2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| AAV Vector & Virus | Long-term expression | VC146816 | View Product |
| Adenovirus | Transient expression | A146816 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG146816 | View Product |
| Gene knockout (non-viral) | PG146816 | View Product | |
| Gene knockout (AAV) | VG146816 | View Product | |
| CRISPR Activation | Gene activation | LA146816 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS146816 | View Product |
| Gene knockdown (AAV) | VS146816 | View Product | |
| ORF Vector | Template DNA | PC146816 | View Product |
Mouse Tmc2 Gene Overview
| Gene Name | transmembrane channel-like gene family 2 |
|---|---|
| Gene Symbol | Tmc2 |
| Synonyms | CWEA2 |
| NCBI ID | 192140 |
| Ensembl ID | ENSMUSG00000060332 |
| Uniprot ID | Q8R4P4 |
| Gene Type | Protein coding |
Gene Summary
Enables mechanosensitive monoatomic ion channel activity and voltage-gated calcium channel activity. Acts upstream of or within several processes, including calcium ion transmembrane transport; detection of mechanical stimulus involved in sensory perception of sound; and vestibular reflex. Located in cuticular plate and stereocilium tip. Is expressed in inner ear. Orthologous to human TMC2 (transmembrane channel like 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Tmc2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC446816 | View Product |
| AAV Vector & Virus | Long-term expression | VC446816 | View Product |
| Adenovirus | Transient expression | A446816 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG446816 | View Product |
| Gene knockout (non-viral) | PG446816 | View Product | |
| Gene knockout (AAV) | VG446816 | View Product | |
| CRISPR Activation | Gene activation | LA446816 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS446816 | View Product |
| Gene knockdown (AAV) | VS446816 | View Product | |
| ORF Vector | Template DNA | PC446816 | View Product |
Rat Tmc2 Gene Overview
| Gene Name | transmembrane channel-like 2 |
|---|---|
| Gene Symbol | Tmc2 |
| Synonyms | |
| NCBI ID | 296153 |
| Ensembl ID | ENSRNOG00000007017 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable mechanosensitive monoatomic ion channel activity and voltage-gated calcium channel activity. Predicted to be involved in detection of mechanical stimulus involved in sensory perception of sound and vestibular reflex. Predicted to act upstream of or within calcium ion transmembrane transport and regulation of calcium ion transmembrane transport. Predicted to be located in cuticular plate and stereocilium tip. Orthologous to human TMC2 (transmembrane channel like 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Tmc2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC646816 | View Product |
| AAV Vector & Virus | Long-term expression | VC646816 | View Product |
| Adenovirus | Transient expression | A646816 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG646816 | View Product |
| Gene knockout (non-viral) | PG646816 | View Product | |
| Gene knockout (AAV) | VG646816 | View Product | |
| CRISPR Activation | Gene activation | LA646816 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS646816 | View Product |
| Gene knockdown (AAV) | VS646816 | View Product | |
| ORF Vector | Template DNA | PC646816 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |