TMPRSS2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TMPRSS2-specific vectors and viral particles designed for reliable TMPRSS2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TMPRSS2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TMPRSS2 Gene Overview
| Gene Name | transmembrane serine protease 2 |
|---|---|
| Gene Symbol | TMPRSS2 |
| Synonyms | PRSS10 |
| NCBI ID | 7113 |
| Ensembl ID | ENSG00000184012 |
| Uniprot ID | O15393 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]
Human TMPRSS2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC147148 | View Product |
| AAV Vector & Virus | Long-term expression | VC147148 | View Product |
| Adenovirus | Transient expression | A147148 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG147148 | View Product |
| Gene knockout (non-viral) | PG147148 | View Product | |
| Gene knockout (AAV) | VG147148 | View Product | |
| CRISPR Activation | Gene activation | LA147148 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS147148 | View Product |
| Gene knockdown (AAV) | VS147148 | View Product | |
| ORF Vector | Template DNA | PC147148 | View Product |
Mouse Tmprss2 Gene Overview
| Gene Name | transmembrane protease, serine 2 |
|---|---|
| Gene Symbol | Tmprss2 |
| Synonyms | D16Ertd61e |
| NCBI ID | 50528 |
| Ensembl ID | ENSMUSG00000000385 |
| Uniprot ID | Q9JIQ8 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable serine-type endopeptidase activity. Involved in proteolysis. Predicted to be located in nucleoplasm and plasma membrane. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; gut; and respiratory system. Orthologous to human TMPRSS2 (transmembrane serine protease 2). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Tmprss2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC447148 | View Product |
| AAV Vector & Virus | Long-term expression | VC447148 | View Product |
| Adenovirus | Transient expression | A447148 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG447148 | View Product |
| Gene knockout (non-viral) | PG447148 | View Product | |
| Gene knockout (AAV) | VG447148 | View Product | |
| CRISPR Activation | Gene activation | LA447148 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS447148 | View Product |
| Gene knockdown (AAV) | VS447148 | View Product | |
| ORF Vector | Template DNA | PC447148 | View Product |
Rat Tmprss2 Gene Overview
| Gene Name | transmembrane serine protease 2 |
|---|---|
| Gene Symbol | Tmprss2 |
| Synonyms | |
| NCBI ID | 156435 |
| Ensembl ID | ENSRNOG00000001976 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein autoprocessing. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human TMPRSS2 (transmembrane serine protease 2). [provided by Alliance of Genome Resources, Apr 2025]
Rat Tmprss2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC647148 | View Product |
| AAV Vector & Virus | Long-term expression | VC647148 | View Product |
| Adenovirus | Transient expression | A647148 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG647148 | View Product |
| Gene knockout (non-viral) | PG647148 | View Product | |
| Gene knockout (AAV) | VG647148 | View Product | |
| CRISPR Activation | Gene activation | LA647148 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS647148 | View Product |
| Gene knockdown (AAV) | VS647148 | View Product | |
| ORF Vector | Template DNA | PC647148 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |