TNC Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TNC-specific vectors and viral particles designed for reliable TNC overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TNC CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TNC Gene Overview
| Gene Name | tenascin C |
|---|---|
| Gene Symbol | TNC |
| Synonyms | GP,JI,TN,HXB,GMEM,TN-C,DFNA56,150-225 |
| NCBI ID | 3371 |
| Ensembl ID | ENSG00000041982 |
| Uniprot ID | P24821 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
Human TNC Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG147187 | View Product |
| Gene knockout (non-viral) | PG147187 | View Product | |
| Gene knockout (AAV) | VG147187 | View Product | |
| CRISPR Activation | Gene activation | LA147187 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS147187 | View Product |
| Gene knockdown (AAV) | VS147187 | View Product | |
| ORF Vector | Template DNA | PC147187 | View Product |
Mouse Tnc Gene Overview
| Gene Name | tenascin C |
|---|---|
| Gene Symbol | Tnc |
| Synonyms | TN,Hxb,Ten,TN-C,cytotactin,tenascin-C,C130033P17Rik |
| NCBI ID | 21923 |
| Ensembl ID | ENSMUSG00000028364 |
| Uniprot ID | Q80YX1 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable fibronectin binding activity; integrin binding activity; and syndecan binding activity. Involved in several processes, including neuromuscular junction development; peripheral nervous system axon regeneration; and regulation of inflammatory response. Acts upstream of or within positive regulation of cell population proliferation; positive regulation of gene expression; and prostate gland development. Located in basement membrane; extracellular region; and interstitial matrix. Part of tenascin complex. Is active in perisynaptic extracellular matrix. Is expressed in several structures, including alimentary system; brain; heart and pericardium; immune system; and skeletal system. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Tnc Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG447187 | View Product |
| Gene knockout (non-viral) | PG447187 | View Product | |
| Gene knockout (AAV) | VG447187 | View Product | |
| CRISPR Activation | Gene activation | LA447187 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS447187 | View Product |
| Gene knockdown (AAV) | VS447187 | View Product | |
| ORF Vector | Template DNA | PC447187 | View Product |
Rat Tnc Gene Overview
| Gene Name | tenascin C |
|---|---|
| Gene Symbol | Tnc |
| Synonyms | |
| NCBI ID | 116640 |
| Ensembl ID | ENSRNOG00000058645 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable integrin binding activity and syndecan binding activity. Involved in several processes, including bud outgrowth involved in lung branching; cellular response to prostaglandin D stimulus; and cellular response to vitamin D. Is active in extracellular matrix of synaptic cleft and glutamatergic synapse. Used to study pulmonary hypertension. Biomarker of cholangiocarcinoma; high grade glioma; myocardial infarction; polycystic kidney disease; and pulmonary hypertension. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; and autosomal dominant nonsyndromic deafness 56. Orthologous to human TNC (tenascin C). [provided by Alliance of Genome Resources, Jul 2025]
Rat Tnc Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG647187 | View Product |
| Gene knockout (non-viral) | PG647187 | View Product | |
| Gene knockout (AAV) | VG647187 | View Product | |
| CRISPR Activation | Gene activation | LA647187 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS647187 | View Product |
| Gene knockdown (AAV) | VS647187 | View Product | |
| ORF Vector | Template DNA | PC647187 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |