TOP1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use TOP1-specific vectors and viral particles designed for reliable TOP1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including TOP1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human TOP1 Gene Overview
| Gene Name | DNA topoisomerase I |
|---|---|
| Gene Symbol | TOP1 |
| Synonyms | TOPI |
| NCBI ID | 7150 |
| Ensembl ID | ENSG00000198900 |
| Uniprot ID | P11387 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]
Human TOP1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC147302 | View Product |
| AAV Vector & Virus | Long-term expression | VC147302 | View Product |
| Adenovirus | Transient expression | A147302 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG147302 | View Product |
| Gene knockout (non-viral) | PG147302 | View Product | |
| Gene knockout (AAV) | VG147302 | View Product | |
| CRISPR Activation | Gene activation | LA147302 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS147302 | View Product |
| Gene knockdown (AAV) | VS147302 | View Product | |
| ORF Vector | Template DNA | PC147302 | View Product |
Mouse Top1 Gene Overview
| Gene Name | topoisomerase (DNA) I |
|---|---|
| Gene Symbol | Top1 |
| Synonyms | Top-1,D130064I21Rik |
| NCBI ID | 21969 |
| Ensembl ID | ENSMUSG00000070544 |
| Uniprot ID | Q04750 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity. Acts upstream of or within DNA replication; DNA topological change; and embryonic cleavage. Located in cytoplasm; male germ cell nucleus; and perikaryon. Is expressed in brain; cerebral cortex subventricular zone; cerebral cortex ventricular layer; cortical plate; and telencephalon. Orthologous to human TOP1 (DNA topoisomerase I). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Top1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC447302 | View Product |
| AAV Vector & Virus | Long-term expression | VC447302 | View Product |
| Adenovirus | Transient expression | A447302 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG447302 | View Product |
| Gene knockout (non-viral) | PG447302 | View Product | |
| Gene knockout (AAV) | VG447302 | View Product | |
| CRISPR Activation | Gene activation | LA447302 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS447302 | View Product |
| Gene knockdown (AAV) | VS447302 | View Product | |
| ORF Vector | Template DNA | PC447302 | View Product |
Rat Top1 Gene Overview
| Gene Name | DNA topoisomerase I |
|---|---|
| Gene Symbol | Top1 |
| Synonyms | Ab2-086 |
| NCBI ID | 24842 |
| Ensembl ID | ENSRNOG00000047611 |
| Uniprot ID | Q9WUL0 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity and chromatin DNA binding activity. Involved in several processes, including DNA topological change; cellular response to luteinizing hormone stimulus; and response to gamma radiation. Located in dense fibrillar component and fibrillar center. Orthologous to human TOP1 (DNA topoisomerase I). [provided by Alliance of Genome Resources, Jul 2025]
Rat Top1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC647302 | View Product |
| AAV Vector & Virus | Long-term expression | VC647302 | View Product |
| Adenovirus | Transient expression | A647302 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG647302 | View Product |
| Gene knockout (non-viral) | PG647302 | View Product | |
| Gene knockout (AAV) | VG647302 | View Product | |
| CRISPR Activation | Gene activation | LA647302 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS647302 | View Product |
| Gene knockdown (AAV) | VS647302 | View Product | |
| ORF Vector | Template DNA | PC647302 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |